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KSR1 — TNF

Text-mined interactions from Literome

Yan et al., Cancer Res 2001 (MAP Kinase Signaling System) : Furthermore, TNF-alpha induced Raf-1 threonine phosphorylation, kinase activity toward MEK1, and association with KSR are also inhibited by kiKSR expression ... Our data also show by sequential in vitro kinase assays that TNF-alpha enhances KSR phosphorylation of Raf-1 on threonine, enhancing Raf-1 kinase activity toward MAP kinase kinase
Yan et al., Cancer Res 2001 (MAP Kinase Signaling System) : Our laboratory reported that kinase suppressor of Ras (KSR) regulates TNF activation of the Raf/mitogen activated protein ( MAP ) kinase/extracellular signal regulated kinase ( ERK ) kinase/ERK signaling cassette by threonine phosphorylation of Raf-1, regulating proliferation and differentiation pathways ... However, TNF activation of p38 or stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase is not inhibited by disruption of KSR signaling