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APOE — LEP

Text-mined interactions from Literome

Huang et al., Am J Physiol Endocrinol Metab 2007 (Weight Loss) : The increase in adipose tissue apoE expression in this model, however, did not require leptin
Shen et al., Physiol Behav 2009 (Body Weight...) : Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats ... To characterize the effect of leptin on apoE gene expression, ob/ob and db/db mice were treated with recombinant mouse leptin ( 3 microg/g daily, i.p. ) or vehicle for 5 days ... We found that the increased hypothalamic apoE mRNA levels occurred only in leptin treated ob/ob, but not in pair fed ob/ob, or db/db, mice, indicating that leptin up-regulated hypothalamic apoE gene expression depends upon an intact leptin receptor, and this effect is not related to the changes in food intake and body weight