Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Eppihimer et al., Shock 1999 (Shock, Septic) : Role of tumor necrosis factor and interferon gamma in endotoxin induced E-selectin expression ... Although IFN-gamma deficiency had no effect on E-selectin expression in other tissues, administration of TN3 to endotoxin challenged, IFN-gamma-deficient mice significantly reduced E-selectin expression to levels observed in endotoxin challenged, wild-type mice that received TN3
Murakami et al., Microvasc Res 2001 : TNF-alpha induced the expression of E-selectin on all three kinds of endothelial cells, but IFN-gamma had no effect on E-selectin expression
Teo et al., The AAPS journal 2005 (Multiple Myeloma...) : They induce an IL-2 mediated primary T cell proliferation with a concomitant increase in IFN-gamma production and decrease the density of TNF-alpha induced cell surface adhesion molecules ICAM-1, VCAM-1, and E-selectin on human umbilical vein endothelial cells
Thornhill et al., J Immunol 1990 : In contrast, IFN-gamma stimulation increases EC binding of T cells but not PMN and enhances ICAM-1 expression but not ELAM-1 or 1.4C3 Ag expression
Doukas et al., J Immunol 1990 : IFN-gamma , which by itself increases EC class I MHC and ICAM-1 but does not induce ELAM-1 expression, has been found to act synergistically with TNF to increase class I expression ... IFN-gamma increases TNF induced ELAM-1 expression such that a greater number of EC express ELAM-1 at both 4 and 24 h in the presence of IFN-gamma plus TNF compared to cultures treated with TNF alone, although the maximal level of surface expression on individual cells is not increased
Leeuwenberg et al., J Immunol 1990 : IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro ... Whereas IFN-gamma per se did not induce expression of ELAM-1 , it enhanced and prolonged the expression of ELAM-1
Tabibzadeh et al., J Clin Endocrinol Metab 1994 : Expression of E-selectin on endothelial cells was induced only by IL-1 alpha, not by IFN gamma or TNF alpha
Lee et al., J Dermatol Sci 1995 : We have demonstrated that stimulation of HDMEC with IL-1 alpha or TNF alpha leads to transient E-selectin induction which disappears after 48 h, but stimulation of HDMEC with IFN-gamma resulted in delayed E-selectin induction which was seen at 48 h of incubation and persisted until 72 h after stimulation
Scholz et al., Transplantation 1996 (Cytomegalovirus Infections) : Whereas oxidative stress alone did not modulate any surface molecule expression, the IFN-gamma mediated expression of HLA-ABC and HLA-DR and the IL-1 mediated expression of ICAM-1, but not of ELAM-1 and VCAM-1 ( IL-1 + TNF-alpha ), was amplified
Henseleit et al., J Pathol 1996 (Dermatitis, Allergic Contact...) : LPS and tumour necrosis factor-alpha (TNF-alpha), but not interleukin-4 (IL-4) or interferon-gamma (IFN-gamma) , induced a transient expression of E-selectin , both when injected in vivo and when added to endothelial cell lines in vitro
Savage et al., J Pathol 1997 : Expression of E-selectin on glomerular endothelial cells ( ECs ) was induced by interleukin-1 (IL-1), tumour necrosis factor (TNF), interferon-gamma (IFN-gamma) and granulocyte/ macrophage-colony stimulating factor ( GM-CSF ) ; this induction was inhibited by transforming growth factor beta ( TGF beta ) and by IL-4
Mizutani et al., Arch Dermatol 1997 (Dermatitis, Allergic Contact...) : While interferon gamma strongly induced E-selectin expression on endothelial cells in normal skin, it failed to induce endothelial E-selectin expression in the NA
Okada et al., Ann Med Interne (Paris) 1997 : IFN gamma did not cause any changes in the expression of ELAM-1 , VCAM-1, and ICAM-1
Strindhall et al., Scand J Immunol 1997 : The aim of the present study was to investigate if altered protein glycosylation could explain the IFN-gamma induced persistent surface expression of E-selectin ... When HUVEC were incubated with monesin, a potent inhibitor of late Golgi function, together with both TNF-alpha and IFN-gamma, the additive effect of IFN-gamma on E-selectin expression was almost abolished
Shen et al., J Virol 1997 : TNF-alpha significantly enhanced WNV induced increases in E-selectin , P-selectin, ICAM-1, and VCAM-1 expression, while IFN-gamma enhanced WNV induced ICAM-1 expression