Gene interactions and pathways from curated databases and text-mining

◀ Back to EGFR

EGFR — GRAP2

Text-mined interactions from Literome

Kolb et al., Int J Cancer 2007 (Pancreatic Neoplasms) : HRGs induced phosphorylation of different ErbB receptors as well as activation of MAPK, p38MAPK , JNK and PI3K in a cell- and ligand-specific manner
Muscella et al., Biochem Pharmacol 2009 : Inhibition or down regulation of EGFR reduced ( 1 ) the phosphorylation of MAPK/p38 , ( 2 ) the cisplatin provoked activation of PKC-epsilon, and ( 3 ) the activation of caspase-7 and PARP cleavage and the overall cells sensitivity to cisplatin
Hwang et al., Mol Nutr Food Res 2011 (Fibrosarcoma...) : Capsaicin inhibited the EGF induced invasion and migration of human fibrosarcoma cells via EGFR dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen activated protein kinase ( MAPK ), and AP-1 signaling, leading to the down-regulation of MMP-9 expression