◀ Back to MAPKAP1

MAPKAP1 — TSC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) → TSC1/TSC2 complex (TSC1-TSC2) (modification, collaborate)
  Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Huang et al., Mol Cell Biol 2008 : However, how mTORC2 is regulated and whether the TSC1-TSC2 complex is involved are unknown ... Our data also suggest that the TSC1-TSC2 complex positively regulates mTORC2 in a manner independent of its GTPase activating protein activity toward Rheb ... These data demonstrate that the TSC1-TSC2 complex inhibits mTORC1 and activates mTORC2 , which through different mechanisms promotes Akt activation
Gao et al., Biol Reprod 2009 : The abundance of FRAP1, RAPTOR, RICTOR, TSC1 , and TSC2 mRNAs in endometria was unaffected by pregnancy status or by day of the estrous cycle or pregnancy ; however, levels of LST8, MAPKAP1 , RHEB, and EIF4EBP1 mRNA increased in endometria during early pregnancy