Srinivasan et al., Mol Cell Neurosci 2007
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Our findings support a role for TACE in the proteolytic cleavage of p75NTR and light induced apoptosis
Kenchappa et al., J Biol Chem 2010
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Together, these results demonstrate that p75NTR mediated activation of JNK3 is required for up-regulation of TACE , which promotes receptor proteolysis, leading to prolonged activation of JNK3 and subsequent apoptosis in sympathetic neurons