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IL1B — NLRP3

Text-mined interactions from Literome

Stehlik et al., J Immunol 2003 : We also show that expression of the PAAD/PYRIN family proteins pyrin or cryopyrin/PYPAF1/NALP3 individually inhibits IL-1beta secretion but that coexpression of ASC with these proteins results in enhanced IL-1beta secretion
Dowds et al., J Biol Chem 2004 : Cryopyrin induced interleukin 1beta secretion in monocytic cells : enhanced activity of disease associated mutants and requirement for ASC ... The induction of cryopyrin activity by enforced oligomerization in THP-1 cells resulted in ASC binding and the secretion of IL-1beta , an effect that was abolished by the inhibition of ASC expression with small interfering RNAs ... Thus, cryopyrin mediated IL-1beta secretion requires ASC in monocytic cells
Kanneganti et al., Nature 2006 (Inflammation) : Cryopyrin and ASC are essential for caspase-1 activation and IL-1beta and IL-18 production in response to bacterial RNA and the imidazoquinoline compounds R837 and R848 ... Furthermore, we show that Toll-like receptors and cryopyrin control the secretion of IL-1beta and IL-18 through different intracellular pathways
Mariathasan et al., Nature 2006 (Inflammation) : Macrophages exposed to Gram positive Staphylococcus aureus or Listeria monocytogenes, however, required both ASC and cryopyrin to activate caspase-1 and secrete IL-1beta
Kanneganti et al., J Biol Chem 2006 : Stimulation of macrophages with dsRNA, viral RNA, or its analog poly ( I:C ) induced the secretion of IL-1beta and IL-18 in a cryopyrin dependent manner ... Finally, cryopyrin was required for IL-1beta production in response to poly ( I:C ) in vivo
Li et al., J Immunol 2008 (Inflammation) : In this study we show that, in human and mouse macrophages, alum induced secretion of IL-1beta , IL-18, and IL-33 is mediated by the NLR ( nucleotide binding domain leucine-rich repeat containing ) protein NLRP3 and its adaptor ASC, but not by NLRC4
Franchi et al., Immunol Rev 2009 (Autoimmune Diseases...) : In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4, Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1 beta
Yamasaki et al., J Biol Chem 2009 (Inflammation) : NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury
Duncan et al., J Immunol 2009 (Inflammation...) : Isolated N. gonorrhoeae lipooligosaccharide, a known virulence factor from this bacterium that is elaborated from the bacterium in the form of outer membrane blebs, activates both NLRP3 induced IL-1beta secretion and pyronecrosis
Harder et al., J Immunol 2009 (Disease Models, Animal...) : In vivo experiments revealed that Nlrp3 was critical for the production of IL-1beta but was not important for survival in a mouse model of S. pyogenes peritoneal infection
Ekman et al., Immunology 2010 : NLRP3 activation with alum caused interleukin-1beta secretion and facilitated migration
Meixenberger et al., J Immunol 2010 : RNA interference and inhibitor experiments in human PBMCs as well as experiments in Nlrp3 and Rip2 knockout bone marrow derived macrophages demonstrated that the Listeria induced IL-1beta release was dependent on ASC, caspase-1, and NLRP3 , whereas NOD2, Rip2, NLRP1, NLRP6, NLRP12, NLRC4, and AIM2 appeared to be dispensable ... In addition, an LLO dependent but cathepsin B-independent NLRP3 activation might contribute to some extent to the IL-1beta production in L. monocytogenes infected cells
He et al., J Immunol 2010 (Chlamydia Infections...) : TLR2 was required for induction of pro-IL-1beta, whereas the NLRP3/ASC was required for caspase-1 activation and pro-IL-1beta cleavage to produce mature IL-1beta
Verma et al., Arthritis Rheum 2010 (Cryopyrin-Associated Periodic Syndromes...) : M299V is an activating mutation in NLRP3 resulting in elevated spontaneous caspase 1 activity and IL-1beta levels