Gene interactions and pathways from curated databases and text-mining

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IL1B — TYR

Text-mined interactions from Literome

Swope et al., J Invest Dermatol 1994 : We have now also shown that interleukin-1 beta induces an inhibiting effect on neonatal melanocyte tyrosinase activity with little effect on melanocyte proliferation
Chin et al., J Immunol 1993 : Conversely, the IL-1 beta converting enzyme inhibitor, Ac-Tyr-Val-Ala-Asp-CHO ( L-709,049 ) and the anti-inflammatory agent [ 5- ( 4-pyridyl ) 6 ( 4-fluorophenyl ) -2,3-dihydroimidazo ( 2,1-b ) thiazole ] ( SK & F 86002 ) inhibited IL-1 beta release in both the standard and staged release assays with IC50 of 1 microM
Hara et al., Proc Natl Acad Sci U S A 1997 (Brain Ischemia...) : Only z-VAD.FMK and acetyl-Tyr-Val-Ala-Asp-chloromethylketone reduced brain swelling, and N-benzyloxycarbonyl-Asp-Glu-Val-Asp-fluoromethylketone did not attenuate the ischemia induced increase in tissue IL-1beta levels