◀ Back to PTPN11

JAK2 — PTPN11

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: JAK2 → PTPN11 (directlyDecreases, PTPN11 Activity, JAK2 Activity)
  Evidence: SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus.
• KEGG Jak-STAT signaling pathway: JAK1/JAK2/JAK3/TYK2 → PTPN11 (protein-protein, phosphorylation)
• KEGG Adipocytokine signaling pathway: JAK2 → PTPN11 (protein-protein, activation)
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database SHP2 signaling: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SHP2 (PTPN11) (translocation, activates) Wu et al., J Biol Chem 2002
  Evidence: assay
• NCI Pathway Database IFN-gamma pathway: IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2) → SHP2 (PTPN11) (modification, collaborate) You et al., Mol Cell Biol 1999, Krause et al., Mol Cell Proteomics 2002, Igarashi et al., J Biol Chem 1994, Marsters et al., Proc Natl Acad Sci U S A 1995, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL5-mediated signaling events: GRB2 (GRB2) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: physical interaction
• NCI Pathway Database IL5-mediated signaling events: GRB2 (GRB2) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2/GRB2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11-GRB2) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: physical interaction
• NCI Pathway Database IL5-mediated signaling events: IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2/GRB2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11-GRB2) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → SHP2 (PTPN11) (modification, collaborate) Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → SHP2 (PTPN11) (modification, collaborate) Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: SHP2 (PTPN11) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: SHP2 (PTPN11) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database GMCSF-mediated signaling events: GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer) complex (CSF2RB-JAK2-CSF2-CSF2RA) → GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHP2 complex (CSF2RB-JAK2-PTPN11-CSF2-CSF2RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Adachi et al., J Immunol 1999
  Evidence: physical interaction
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → SHP2 (PTPN11) (translocation, activates) Wu et al., J Biol Chem 2002
  Evidence: assay
• NCI Pathway Database IL5-mediated signaling events: IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2) → SHP2 (PTPN11) (modification, collaborate) Pazdrak et al., J Exp Med 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL5-mediated signaling events: IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2 complex (CSF2RB-IL5-IL5RA-JAK2) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL5-mediated signaling events: SHP2 (PTPN11) → IL5/IL5RA/CSF2RB (hexamer)/JAK2/JAK2/SHP2 complex (CSF2RB-IL5-IL5RA-JAK2-PTPN11) (modification, collaborate)
  Pazdrak et al., J Exp Med 1997
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: JAK2 → PTPN11 (reaction) Stahl et al., Science 1995*, Bone et al., J Biol Chem 1997, Symes et al., Curr Biol 1997*, Carpenter et al., Proc Natl Acad Sci U S A 1998*, Schaper et al., Biochem J 1998
• Reactome Reaction: JAK2 → PTPN11 (indirect_complex) Stahl et al., Science 1995*, Bone et al., J Biol Chem 1997, Symes et al., Curr Biol 1997*, Carpenter et al., Proc Natl Acad Sci U S A 1998*, Schaper et al., Biochem J 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTPN11 — JAK2 (direct interaction, enzymatic study) Yin et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTPN11 — JAK2 (direct interaction, pull down) Yin et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTPN11 — JAK2 (direct interaction, enzymatic study) Tauchi et al., Blood 1996*
• IRef Biogrid Interaction: PTPN11 — JAK2 (physical association, affinity chromatography technology) Maegawa et al., Biochem Biophys Res Commun 1996*
• IRef Hprd Interaction: PTPN11 — JAK2 (in vivo) Fuhrer et al., J Biol Chem 1995*, Maegawa et al., Biochem Biophys Res Commun 1996*, Yin et al., J Biol Chem 1997*
• IRef Ophid Interaction: PTPN11 — JAK2 (aggregation, confirmational text mining) Yin et al., J Biol Chem 1997*
• IRef Ophid Interaction: PTPN11 — JAK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 1999 (Obesity) : These data suggest that activation of SHP-2 by the leptin receptor results in a decreased phosphorylation of JAK2 and may act to attenuate leptin signal transduction
Stofega et al., Mol Endocrinol 2000 : These data suggest that tyrosine 595 is a major site of interaction of GHR with SHP-2, and that GHR bound SHP-2 negatively regulates GHR/JAK2 and STAT5B signaling
Kim et al., J Biol Chem 2006 : Based on our previous finding that in cultured rat brain microglia, gangliosides induce rapid and transient activation of the JAK-STAT pathway, we hypothesized that raft mediated SHP-2 activation is involved in transient activation of JAK-STAT signaling by gangliosides
Jia et al., PloS one 2010 : In addition, NS1 expression induces up-regulation of the JAK/STAT inhibitors, SOCS1 and SOCS3
Watanabe et al., J Biol Chem 1996 : Further analyses of the role of JAK2 in c-fos gene activation in BA/F3 cells expressing hGMR revealed that delta JAK2 inhibited hGM-CSF induced phosphorylation of Shc and protein tyrosine phosphatase 1D
Mohi et al., Mol Biol Cell 1998 : Conversely, activation of the chimeric Jak2 induced neither phosphorylation of Shc or SHP-2 nor activation of the c-fos promoter