Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of KDR-PTPN11
→
TNF
(increases)
Evidence: TNF- inhibits VEGF signaling by recruiting SHP-2 to the VEGFR2 in ECs (42).
OpenBEL Selventa BEL large corpus:
PTPN11
→
KDR
(increases, KDR Activity, PTPN11 Activity)
Soldi et al., EMBO J 1999 Evidence: Through its phosphorylated tyrosine residues, the activated VEGFR-2 associates with the adapter molecules Shc, Grb2 and Nck, to Ras GTPase activating protein, p59fyn, pp62yes and phospholipase Cg, and to the tyrosine phosphatases SHP-1 and SHP-2
OpenBEL Selventa BEL large corpus:
KDR
→
PTPN11
(decreases, PTPN11 Activity, KDR Activity)
Evidence: TNF- inhibits VEGF signaling by recruiting SHP-2 to the VEGFR2 in ECs (42).
NCI Pathway Database SHP2 signaling:
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
→
GAB1/SHP2/PKA/eNOS complex (GAB1-PTPN11-PRKACA-NOS3)
(modification, activates)
Lu et al., Proc Natl Acad Sci U S A 2011 Evidence: mutant phenotype, physical interaction
NCI Pathway Database SHP2 signaling:
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
→
SHP2 (PTPN11)
(modification, activates)
Lu et al., Proc Natl Acad Sci U S A 2011 Evidence: mutant phenotype, physical interaction