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These studies reveal a novel role for JNK, p38 kinase, CK2, and c-Jun/AP-1 in the TGF-beta induced expression of apoE Kim et al., Exp Cell Res 2013
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Overexpression of ApoE in BMMs and RAW264.7 cells significantly blocked the induction of c-Fos and nuclear factor of activated T cell c1 ( NFATc1 ), transcription factors critical for expression of osteoclast marker genes, by receptor activator of nuclear factor ?B ligand ( RANKL ), the osteoclast differentiation factor