Kashiwabara et al., J Mol Endocrinol 2009
:
Using kidney derived CV1 cells, we investigated the role of PIT1 in the expression of Tshb gene ... Transactivation of TSHbeta promoter requires PIT1 binding site upstream to GATA-REs ( PIT1-US ), and the spacing between PIT1-US and GATA-REs strictly determines the cooperation between PIT1 and GATA2
Pellegrini-Bouiller et al., J Clin Endocrinol Metab 1996
:
The pituitary-specific transcription factor Pit-1/GHF1 regulates the expression of PRL, GH, and TSH beta genes through binding to specific regions of the promoters of these genes