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REG1A — TOP2A

Text-mined interactions from Literome

Olland et al., J Biol Chem 1999 : The ATPase activity of Top2- ( 1-409 ) is inhibited by ICRF-193 , suggesting that the bisdioxopiperazine class of DNA topoisomerase II inhibitors directly interacts with the paired ATPase domains of the enzyme
Kawatani et al., Chem Biol 2011 : Here, we identify a target of BNS-22 by proteomic profiling analysis, which suggests that BNS-22 belongs to the same cluster as ICRF-193 , a DNA topoisomerase II (TOP2) catalytic inhibitor
Lin et al., J Biol Chem 2013 : Second, ICRF-187 , a Top2 catalytic inhibitor known to deplete Top2ß, specifically sensitized MEFs to CPT. To explore the molecular basis for CPT hypersensitivity in Top2ß-deficient cells, we found that upon CPT exposure, the RNA polymerase II large subunit ( RNAP LS ) became progressively depleted, followed by recovery to nearly the original level in wild-type MEFs, whereas RNAP LS remained depleted without recovery in Top2ß-deficient cells