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SHH — WNT4

Text-mined interactions from Literome

Treichel et al., Genes Dev 2003 : We present evidence that mBtd is required during early limb development to maintain, but not to initiate Wnt/beta-catenin dependent FGF, Shh , and BMP mediated signaling
Robertson et al., Dev Dyn 2004 : We demonstrate that activation of Wnt signaling results in an inhibition of the Shh response in neural tissue
Lei et al., Dev Cell 2006 : Here, we show that Wnt pathway inhibitors regulate the threshold response of a ventral Shh target gene, Nkx2.2, to establish its restricted expression in the ventral spinal cord
Iwatsuki et al., Proc Natl Acad Sci U S A 2007 : Exogenously added Shh suppressed expression of endogenous Shh and inhibited Wnt/beta-catenin signaling ( assessed in TOPGAL mice ), further implicating Shh as an inhibitor of the Wnt/beta-catenin pathway
Quinlan et al., Neural development 2009 : Using an in ovo electroporation approach, we show that Wnt4 expression in the thalamus is negatively regulated by Sonic hedgehog (Shh) signalling from the zona limitans intrathalamica ( ZLI ), a known organising centre of forebrain development ... By demonstrating that Wnt4 expression in the thalamus is repressed by Shh from the ZLI we reveal an additional level of interaction between these two pathways and provide an example for the cross-regulation between patterning centres during forebrain regionalisation
Martinez-Ferre et al., J Neurosci 2013 : Here we investigated a key role of Wnt signaling in the molecular regulation of ZLI positioning and Shh expression, using experimental embryology in ovo in the chick