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CANX — MAP2K1

Text-mined interactions from Literome

Haworth et al., J Biol Chem 2003 (Acidosis) : Furthermore, inhibition of MEK1/2 by pretreatment of NRVM with two structurally distinct inhibitors, PD98059 ( 30 microM ) or UO126 ( 3 microM ), inhibited the activation of ERK and p90RSK and abolished the stimulation of NHE activity by sustained ( 3 min ) intracellular acidosis
Sananbenesi et al., J Neurosci 2003 (MAP Kinase Signaling System) : Intrahippocampal injection of the selective Mek-1/2 inhibitor U0126 or CRF2 antagonist antisauvagine-30 ( aSvg-30 ) prevented stress enhanced fear conditioning and Mek-1/2 dependent activation of Erk-1/2 and p90Rsk-1
Wu et al., Cell Microbiol 2006 (MAP Kinase Signaling System) : Our results showed that phosphorylated mitogen activated protein kinase ( MAPK ) kinase ( MEK) 1/2, p44/p42 MAPK and p90 ribosomal S6 kinase (p90RSK) were observed and this pathway was inhibited by MEK1/2 inhibitors U0126 and PD98059
Pike et al., Cell Signal 2013 : A lack of MEK1 or ability to accumulate tMEK resulted in the absence of the feedback inhibition of ERK and p90RSK activations