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APEX1 — NFKB1

Text-mined interactions from Literome

Ozaki et al., FASEB J 2002 : In a model of mouse hepatic ischemia/reperfusion ( I/R ), recombinant adenoviral overexpression of ref-1 resulted in suppression of reperfusion stimulated oxidative stress, NF-kB induction, apoptosis, and acute injury, whereas down-regulation of endogenous ref-1 by adenoviral expression of antisense ref-1 led to an increase in these reperfusion induced parameters
Angkeow et al., Cell Death Differ 2002 : Forced cytoplasmic overexpression of ref-1 suppressed H/R induced oxidative stress ( H ( 2 ) O ( 2 ) production ), NF-kappaB activation, and apoptosis, and also mitigated rac1 regulated H ( 2 ) O ( 2 ) production and NF-kappaB transcriptional activity
Ribardo et al., Microb Pathog 2002 (Calcium Signaling) : Taken together, a link between Act induced calcium release, regulation of downstream kinase cascades and Ref-1 , and activation of NF-kappa B leading to PGE ( 2 ) and TNF alpha production was established
Dai et al., Free Radic Biol Med 2006 (Atherosclerosis...) : Furthermore, overexpressed Ref-1 upregulated NF-kappaB and MCP-1 promoter activity, and antisense Ref-1 reduced Hcy induced NF-kappaB DNA binding activity and MCP-1 secretion ... These data indicate that Hcy induced ROS upregulate the expression and translocation of Ref-1 via NADPH oxidase, and then Ref-1 increases NF-kappaB activity and MCP-1 secretion in human monocytes/macrophages, which may accelerate the development of atherosclerosis
O'Hara et al., J Immunol 2006 (Helicobacter Infections) : Small interfering RNA mediated silencing of APE-1/Ref-1 inhibited basal and H. pylori induced AP-1 and NF-kappaB DNA binding activity without affecting the nuclear translocation of these transcription factors and also reduced H. pylori induced IL-8 mRNA and protein
Song et al., Immunology 2008 (Translocation, Genetic) : Redox factor-1 mediates NF-kappaB nuclear translocation for LPS induced iNOS expression in murine macrophage cell line RAW 264.7
O'Hara et al., Cytokine 2009 : Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation