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CSN3 — NFKB1

Text-mined interactions from Literome

Hong et al., FEBS Lett 2001 : Overexpression of CSN3 inhibits NF-kappaB activation triggered by tumor necrosis factor (TNF), but not interleukin-1 (IL-1) ... Moreover, overexpression of CSN3 also inhibits NF-kappaB activation triggered by proteins involved in TNF signaling, including TNF-R1, TRAF2, RIP, and NIK, but not by TRAF6, a protein involved in IL-1 signaling
Kweon et al., Biochem Biophys Res Commun 2006 (Inflammation...) : Moreover, casein kinase 2 ( CK2 ) is involved in synergistic induction of NF-kappaB via a mechanism dependent on phosphorylation of p65 at both Ser536 and Ser276 sites
Schweitzer et al., EMBO J 2007 : CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha ... For the first time, we show here an inducible interaction of the CSN with IkappaBalpha and that the CSN controls IkappaBalpha and NF-kappaB activity ... Strikingly, disruption of the CSN by a small interfering RNA mediated knockdown of single CSN subunits results in a reduced re-accumulation of IkappaBalpha and prolonged nuclear translocation of NF-kappaB in TNFalpha stimulated cells
Willems et al., Molecular cancer 2010 (Liposarcoma, Myxoid) : Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option