◀ Back to BMP4
BMP4 — BMPR1A
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of BMPR1A-FKBP1A
→
BMP4
(decreases)
Rajan et al., J Cell Biol 2003*
Evidence: We found that FKBP12 complexed with BMPR-IA in CNS stem cells, and that this complex dissociated when cells were treated with BMP4 (Fig. 5 A).
-
BioCarta alk in cardiac myocytes:
BMPR-II/ALK3 complex (BMPR2-BMPR1A)
→
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
BMPR-II/ALK3 complex (BMPR2-BMPR1A)
→
BMP (BMP7/BMP2/BMP5/BMP10/BMP4)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
→
BMP (BMP7/BMP2/BMP5/BMP10/BMP4)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
NOGGIN (NOG)
→
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
(modification, inhibits)
-
BioCarta alk in cardiac myocytes:
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
→
CHORDIN (CHRD)
(modification, activates)
-
NCI Pathway Database BMP receptor signaling:
FS (FST)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
FS (FST)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
RGM family (RGMB/RGMA/HFE2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR2 (homodimer) complex (BMPR2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BAMBI (BAMBI)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
TAK1/SMAD6 complex (MAP3K7-SMAD6)
(modification, activates)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, activates)
Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database BMP receptor signaling:
GREM1 (GREM1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/GREM1 complex (BMP4_BMP2-GREM1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMP2-4/GREM1 complex (BMP4_BMP2-GREM1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
→
BMP2-4/GREM1 complex (BMP4_BMP2-GREM1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Hsu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
USAG1 (SOSTDC1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
→
BMP2-4/USAG1 complex (BMP4_BMP2-SOSTDC1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Yanagita et al., Biochem Biophys Res Commun 2004, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A)
→
ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A)
→
SMAD1 (SMAD1)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A)
→
GADD34/PP1CA complex (ZFYVE16-PPP1R15A-PPP1CA)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-ZFYVE16-PPP1CA-PPP1R15A)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
ENDOFIN/SMAD1 complex (ZFYVE16-SMAD1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
SMAD1 (SMAD1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
GADD34/PP1CA complex (ZFYVE16-PPP1R15A-PPP1CA)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Babitt et al., J Biol Chem 2005, Shi et al., J Cell Sci 2007, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
SMAD7/SMURF1 complex (SMAD7-SMURF1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD7/SMURF1 complex (SMAD7-SMURF1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD1 (SMAD1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD1 (SMAD1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-SMAD7-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
XIAP (XIAP)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
(modification, collaborate)
Yamaguchi et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
XIAP (XIAP)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Yamaguchi et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Yamaguchi et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/NOG complex (BMP4_BMP2-NOG)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/NOG complex (BMP4_BMP2-NOG)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/NOG complex (BMP4_BMP2-NOG)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
NOG (NOG)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Zimmerman et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/FETUA complex (BMP4_BMP2-AHSG)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/FETUA complex (BMP4_BMP2-AHSG)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/FETUA complex (BMP4_BMP2-AHSG)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
FETUA (AHSG)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Demetriou et al., J Biol Chem 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
CHRD (CHRD)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRDL1 complex (BMP4_BMP2-CHRDL1)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
CHRDL1 (CHRDL1)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nakayama et al., Dev Biol 2001, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
CER1 (CER1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CER1 complex (BMP4_BMP2-CER1)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CER1 complex (BMP4_BMP2-CER1)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CER1 complex (BMP4_BMP2-CER1)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4 (homodimer) complex (BMP4_BMP2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Belo et al., Genesis 2000, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994
Evidence: mutant phenotype, physical interaction, other species
-
WikiPathways ESC Pluripotency Pathways:
BMP4
→
Complex of ACTR2-BMPR1A-ACVR1-BMPR2-BMPR1B
(activation)
-
WikiPathways Heart Development:
BMP4
→
BMPR2/BMPR1A
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
BMPR1A
—
BMP4
Kirsch et al., Nat Struct Biol 2000*, Keller et al., Nature structural & molecular biology 2004*
-
IRef Bind_translation Interaction:
BMPR1A
—
BMP4
(x-ray crystallography)
Kirsch et al., Nat Struct Biol 2000*
-
IRef Biogrid Interaction:
BMPR1A
—
BMP4
(direct interaction, pull down)
ten Dijke et al., J Biol Chem 1994
-
MIPS CORUM BMP2-BRIA complex:
BMP2-BRIA complex complex (BMP2-BMP4-BMPR1A)
Kirsch et al., Nat Struct Biol 2000*
-
IRef Corum Interaction:
Complex of BMPR1A-BMP4-BMP2
(association, molecular sieving)
Kirsch et al., Nat Struct Biol 2000*
-
IRef Hprd Interaction:
BMPR1A
—
BMP4
(in vitro)
Hatta et al., Biopolymers 2000*, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nishitoh et al., J Biol Chem 1996*
-
IRef Intact Interaction:
BMPR1A
—
BMP4
(direct interaction, surface plasmon resonance)
Szláma et al., FEBS J 2010
-
IRef Intact Interaction:
BMPR1A
—
BMP4
(physical association, surface plasmon resonance)
Tanaka et al., FEBS J 2010
-
IRef Ophid Interaction:
BMPR1A
—
BMP4
(aggregation, confirmational text mining)
Nishitoh et al., J Biol Chem 1996*
-
IRef Ophid Interaction:
BMPR1A
—
BMP4
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Murali et al., Development 2005
:
These studies provide direct genetic evidence that
Bmpr1a and Bmpr1b play redundant roles during retinal development, and that different threshold levels of
Bmp signaling
regulate distinct developmental programs such as patterning, growth and differentiation of the retina
Yoon et al., Proc Natl Acad Sci U S A 2005
(Osteochondrodysplasias) :
In summary, our study demonstrates that
BMPR1A and BMPR1B are functionally redundant during early chondrogenesis and that
BMP signaling is
required for chondrocyte proliferation, survival, and differentiation in vivo
Kano et al., Endocrinology 2005
:
Furthermore, intracellular
BMP signaling was markedly suppressed by dexamethasone treatment and the expression of ALK-2,
ALK-3 , and BMPRII was significantly
inhibited by dexamethasone
Miyoshi et al., Biol Reprod 2006
:
Since overexpression of
BMPR1A and BMPR1B, but not SMADs, significantly
enhanced the
BMP responses, these type I receptors were revealed to be limiting factors for BMP signaling in KGN cells
Huang et al., Proc Natl Acad Sci U S A 2009
:
Overexpression of constitutively active
BMP receptor ( CA ) -BMPr1A or CA-BMPr1B
induces commitment in the absence of BMP2/4, whereas overexpression of a dominant negative receptor
dominant-negative-BMPr1A suppresses commitment induced by BMP
Matsumoto et al., Steroids 2013
:
The expression of BMPRII was increased by estrogen in MC3T3-E1 cells, and inhibition of BMPRII or
ALK-2/3 signaling
impaired the effect of estrogen on
BMP-4 signaling