Gene interactions and pathways from curated databases and text-mining

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IL3 — SHC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Bone et al., Cell Signal 2000 (Leukemia, Erythroblastic, Acute) : Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation
Matsuguchi et al., J Biol Chem 1994 (Leukemia, Megakaryoblastic, Acute) : Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL ... Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL
Dorsch et al., Biochem Biophys Res Commun 1994 : Tyrosine phosphorylation of Shc is induced by IL-3 , IL-5 and GM-CSF
Liu et al., Mol Cell Biol 1994 : We recently reported that interleukin-3 , Steel factor, and erythropoietin all induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cell lines
Owen-Lynch et al., J Biol Chem 1995 : Both IL-3 and v-Abl stimulated the tyrosine phosphorylation of SHC and GTPase activating protein
O'Farrell et al., Blood 1996 : In B6M cells, both IL-3 and SCF stimulate phosphorylation of Shc and activation of the Ras, Raf-1, MAPK pathway
Gotoh et al., EMBO J 1996 : IL-3 stimulates tyrosine phosphorylation of the Shc adaptor protein and thereby formation of a complex of Shc with Grb2 at phosphorylated tyrosine ( Y ) residue 317-Shc ... We examined the possible involvement of Shc in the antiapoptotic activity of IL-3
Chin et al., Biochem Biophys Res Commun 1997 : Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc , SHP-2, and Cbl in hematopoietic cells ... The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3 containing adapter protein CrkL and its transient association with tyrosine phosphorylated SHP-2, Shc , and Cbl in a murine IL-3 dependent cell line, 32D, expressing the Epo receptor (EpoR)