◀ Back to IL3
IL3 — SHC1
Pathways - manually collected, often from reviews:
-
BioCarta il 3 signaling pathway:
IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
SHIP (INPP5D)
(modification, collaborate)
Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
SHIP (INPP5D)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
SHC (SHC1)
(modification, collaborate)
Bone et al., Cell Signal 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
SHC (SHC1)
(modification, collaborate)
Bone et al., Cell Signal 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA)
→
SHC (SHC1)
(modification, collaborate)
Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA)
(modification, collaborate)
Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
SHC (SHC1)
→
IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA)
(modification, collaborate)
Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
IL3
→
SHC1
(indirect_complex)
-
Reactome Reaction:
IL3
→
SHC1
(reaction)
Gu et al., Mol Cell Biol 2000, Pratt et al., J Biol Chem 1996
Text-mined interactions from Literome
Bone et al., Cell Signal 2000
(Leukemia, Erythroblastic, Acute) :
Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2
following IL-3 stimulation
Matsuguchi et al., J Biol Chem 1994
(Leukemia, Megakaryoblastic, Acute) :
Shc phosphorylation in myeloid cells is
regulated by granulocyte macrophage colony stimulating factor,
interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL ...
Shc phosphorylation in myeloid cells is
regulated by granulocyte macrophage colony stimulating factor,
interleukin-3 , and steel factor and is constitutively increased by p210BCR/ABL
Dorsch et al., Biochem Biophys Res Commun 1994
:
Tyrosine phosphorylation of
Shc is
induced by
IL-3 , IL-5 and GM-CSF
Liu et al., Mol Cell Biol 1994
:
We recently reported that
interleukin-3 , Steel factor, and erythropoietin all
induce the tyrosine phosphorylation of
Shc and its association with Grb2 in hemopoietic cell lines
Owen-Lynch et al., J Biol Chem 1995
:
Both
IL-3 and v-Abl
stimulated the tyrosine phosphorylation of
SHC and GTPase activating protein
O'Farrell et al., Blood 1996
:
In B6M cells, both
IL-3 and SCF
stimulate phosphorylation of
Shc and activation of the Ras, Raf-1, MAPK pathway
Gotoh et al., EMBO J 1996
:
IL-3 stimulates tyrosine phosphorylation of the
Shc adaptor protein and thereby formation of a complex of Shc with Grb2 at phosphorylated tyrosine ( Y ) residue 317-Shc ... We examined the possible
involvement of
Shc in the antiapoptotic activity of
IL-3
Chin et al., Biochem Biophys Res Commun 1997
:
Erythropoietin and
IL-3 induce tyrosine phosphorylation of CrkL and its association with
Shc , SHP-2, and Cbl in hematopoietic cells ... The present study demonstrates that erythropoietin (Epo) and
IL-3 induce tyrosine phosphorylation of the SH2/SH3 containing adapter protein CrkL and its transient association with tyrosine phosphorylated SHP-2,
Shc , and Cbl in a murine IL-3 dependent cell line, 32D, expressing the Epo receptor (EpoR)