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EDN1 — NGF
Text-mined interactions from Literome
Ieda et al., J Clin Invest 2004
:
Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling
nerve growth factor expression ... These findings indicate that
endothelin-1 regulates
NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart
Ieda et al., J Pharmacol Sci 2009
(Death, Sudden, Cardiac...) :
Nerve growth factor (NGF) , a potent chemoattractant, is synthesized abundantly by cardiomyocytes, and is
induced by the upregulation of
endothelin-1 during development
Ieda et al., Curr Cardiol Rev 2009
:
Nerve growth factor (NGF) , a potent chemoattractant, is
induced by
endothelin-1 upregulation during development and is highly expressed in cardiomyocytes
Ladenheim et al., J Neurochem 1993
(Astrocytoma) :
The activation of protein kinase C appears as an obligatory step during these processes, because ( a ) inhibition of protein kinase C by staurosporine blocks the
induction by
endothelin or phorbol esters of both c-fos and
nerve growth factor , and ( b ) phorbol ester evoked down-regulation of protein kinase C completely abolishes the c-fos induction by endothelin, but not that by the beta-adrenergic agonist isoproterenol, a known activator of the cyclic AMP dependent pathway