Gene interactions and pathways from curated databases and text-mining

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EDN1 — NGF

Text-mined interactions from Literome

Ieda et al., J Clin Invest 2004 : Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression ... These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart
Ieda et al., J Pharmacol Sci 2009 (Death, Sudden, Cardiac...) : Nerve growth factor (NGF) , a potent chemoattractant, is synthesized abundantly by cardiomyocytes, and is induced by the upregulation of endothelin-1 during development
Ieda et al., Curr Cardiol Rev 2009 : Nerve growth factor (NGF) , a potent chemoattractant, is induced by endothelin-1 upregulation during development and is highly expressed in cardiomyocytes
Ladenheim et al., J Neurochem 1993 (Astrocytoma) : The activation of protein kinase C appears as an obligatory step during these processes, because ( a ) inhibition of protein kinase C by staurosporine blocks the induction by endothelin or phorbol esters of both c-fos and nerve growth factor , and ( b ) phorbol ester evoked down-regulation of protein kinase C completely abolishes the c-fos induction by endothelin, but not that by the beta-adrenergic agonist isoproterenol, a known activator of the cyclic AMP dependent pathway