Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Stanczyk et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid) : Constitutive expression of both miR-155 and miR-146a was higher in RASFs than in those from patients with osteoarthritis ( OA ), and expression of miR-155 could be further induced by TNFalpha, interleukin-1beta , lipopolysaccharide, poly ( I-C ), and bacterial lipoprotein
Jones et al., Osteoarthritis Cartilage 2009 (Osteoarthritis, Knee) : Over-expression of miR-9 , miR-98 or miR-146 in isolated human chondrocytes reduced interleukin-1 beta (IL-1 beta) induced TNF-alpha production
Yamasaki et al., Arthritis Rheum 2009 (Osteoarthritis) : This study shows that miR-146 is intensely expressed in low-grade OA cartilage and that its expression is induced by stimulation of IL-1beta
Miyaki et al., Arthritis Rheum 2009 (Osteoarthritis, Knee) : We tested the effects of interleukin-1beta (IL-1beta) on miR-140 expression ... The reduction in miR-140 expression in OA cartilage and in response to IL-1beta may contribute to the abnormal gene expression pattern characteristic of OA
Roggli et al., Diabetes 2010 (Inflammation) : We found that IL-1beta and TNF-alpha induce the expression of miR-21, miR-34a, and miR-146a both in MIN6 cells and human pancreatic islets
Akhtar et al., Arthritis Rheum 2010 (Osteoarthritis) : Furthermore, IL-1beta induced activation of signal transduction pathways associated with the expression of MMP-13 down-regulated the expression of miR-27b
Larner-Svensson et al., Respir Res 2010 : Functional studies indicated that IL-1beta induced miR-146a expression does not negatively regulate IL-6 and IL-8 release or basal proliferation ... We have shown that IL-1beta induced miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the MEK-1/2 and JNK-1/2