Gene interactions and pathways from curated databases and text-mining

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HMGB1 — TLR4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jiang et al., Mol Immunol 2008 : As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not ... As shown in in vitro studies, while polyinosinic-polycytidylic acid [ poly ( I:C ) ] and LPS, TLR3 and TLR4 ligands, respectively, can induce HMGB1 release from macrophages, CpG DNA, a TLR 9 ligand, does not
Kaczorowski et al., Transplantation 2009 (Inflammation...) : High mobility group box 1 (HMGB1) is a putative endogenous activator of TLR4
Gauley et al., Autoimmunity 2009 : In murine macrophages ( MPhi ), stimulation of TLR3 and TLR4 , but not TLR9, can cause HMGB1 translocation
Dai et al., J Biol Chem 2010 (Enterocolitis, Necrotizing) : In seeking to understand the mechanisms involved, TLR4 dependent HMGB1 signaling increased RhoA activation in enterocytes, increased phosphorylation of focal adhesion kinase, and increased phosphorylation of cofilin, resulting in increased stress fibers and focal adhesions
Yang et al., Proc Natl Acad Sci U S A 2010 : Inhibition of TLR4 binding with neutralizing anti-HMGB1 mAb or by mutating cysteine 106 prevents HMGB1 activation of cytokine release
Tang et al., J Immunol 2010 (Body Weight...) : Further investigation revealed that TLR4 endogenous ligands high-mobility group box 1 and heat shock protein 22, were systemically upregulated and might be involved in the IL-17 induced TLR4 activation
Yang et al., Mol Cell Biochem 2010 : Further experiments showed that atorvastatin markedly suppressed HMGB1 induced Toll like receptor 4 (TLR4) expression, Nuclear factor kappaB ( NF-?B ) nuclear translocation and DNA binding activity in ECs
Xiang et al., J Immunol 2011 (Disease Models, Animal...) : We show that high mobility group box 1 acting through TLR4 , and a synergistic collaboration with TLR2 and receptor for advanced glycation end products signaling, mediates HS-induced activation of EC NAD ( P ) H oxidase
Mita et al., Fertil Steril 2011 : Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells
Yan et al., Hepatology 2012 (Carcinoma, Hepatocellular...) : Caspase-1 activation was found to occur in hypoxic HCC cells in a process that was dependent on the extracellular release of HMGB1 and subsequent activation of both Toll-like receptor 4 (TLR4)- and receptor for advanced glycation endproducts ( RAGE ) -signaling pathways
Wang et al., Cancer Biol Ther 2012 (Lung Neoplasms) : Notably, we revealed that RAGE and TLR4 were critical for HMGB1 to exert the synergistic function
Zhang et al., Life Sci 2012 : The aim of the present study was to investigate the effect of high mobility group box 1 (HMGB1) , a damage pattern molecule that signals the presence of necrosis, on TLR4 signaling in hepatic stellate cells (HSC) ... As an endogenous ligand of TLR4, HMGB1 activates TLR4 signaling in HSCs to enhance their inflammatory phenotype, indicating that TLR4 signaling need not rely solely on gut derived LPS for activation during liver injury
Ding et al., Gene 2012 (Myocardial Reperfusion Injury) : The results demonstrated that fewer neutrophils infiltrated in the myocardium of TLR4-mutant mice after myocardial I/R and that TLR4 deficiency markedly decreased the ischemic injury caused by ischemia/reperfusion, and inhibited the expression of HMGB1 , TNF-a, and IL-8, all of which were up-regulated by ischemia/reperfusion
Zhang et al., Zhonghua Gan Zang Bing Za Zhi 2012 : [HMGB1 mediated activation of TLR4 signaling in hepatic stellate cells ] ... [HMGB1 mediated activation of TLR4 signaling in hepatic stellate cells ] ... As an endogeous ligand of TLR4, HMGB1 may activate TLR4 signaling and the TLR4 mediated inflammatory response of HSC ... As an endogeous ligand of TLR4, HMGB1 may activate TLR4 signaling and the TLR4 mediated inflammatory response of HSC
Gupta et al., Cell Signal 2013 (Glioma...) : Inhibition of HMGB1 inhibited TLR4 and vice versa suggesting the existence of HMGB1-TLR4 axis in glioma cells
Kohka Takahashi et al., Eur J Pharmacol 2013 : HMGB1 also up-regulated RAGE, but not TLR-2 or TLR-4 , expression on monocytes, which was inhibited by antibodies ( Abs ) against ICAM-1, B7.1, B7.2 and CD40
Bauer et al., Mol Med 2012 (Anoxia...) : These data demonstrate that HMGB1 mediated activation of TLR4 promotes experimental PH and identify HMGB1 and/or TLR4 as potential therapeutic targets for the treatment of PH
Nace et al., Hepatology 2013 (Reperfusion Injury) : Circulating levels of high-mobility group box 1 (HMGB1) were significantly reduced in Alb-TLR4 ( -/- ) mice, compared to WT, Lyz-TLR4 ( -/- ), CD11c-TLR4 ( -/- ) mice and equivalent to global TLR4 ( -/- ) mice, suggesting that TLR4 mediated HMGB1 release from HCs may be a source of HMGB1 after I/R. HCs exposed to hypoxia responded by rapidly phosphorylating the mitogen activated protein kinases, c-Jun-N-terminal kinase (JNK) and p38, in a TLR4 dependent manner ; inhibition of JNK decreased release of HMGB1 after both hypoxia in vitro and I/R in vivo
Kim et al., Mol Med 2013 : We demonstrate that optimal HMGB1 dependent TLR4 activation in vitro requires the coreceptor CD14
Li et al., Inflamm Res 2013 (Liver Failure) : Furthermore, the hepatic levels of HMGB1, TLR4 , caspase3 and P65 were also down-regulated by HMGB1 blockade