Reisman et al., Cell Growth Differ 1993
:
Furthermore, we found that in cotransfection assays, c-Myc trans-activates the p53 promoter as well as a hybrid herpes simplex virus-thymidine kinase promoter containing multiple copies of a synthetic p53 derived c-Myc binding site
Pusch et al., DNA Cell Biol 1997
:
We found that in logarithmically growing cells overexpression of Myc specifically induces thymidine kinase ( TK ) mRNA expression and enzyme activity, whereas loss of one allele of Myc causes downregulation of this enzyme