◀ Back to ICAM1
ICAM1 — IKBKB
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
ICAM1
→
IKBKB
(increases)
Aupperle et al., J Immunol 2001*
Evidence: IKK2 wild-type significantly increased basal ICAM-1 levels, whereas the IKK2 dominant negative construct prevented IL-1 induced ICAM-1 expression.
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OpenBEL Selventa BEL large corpus:
ICAM1
→
IKBKB
(increases, ICAM1 Activity)
Newton et al., J Pharmacol Exp Ther 2007*
Evidence: In these studies, IBN and dominantnegative IKK2, but not dominant-negative IKK1 or an empty (null) virus, prevented the induction of NF-B DNA binding and the induction of NF-B-dependent transcription in A549 cells (Catley et al., 2005). This previous study documented a parallel inhibitory effect on the expression of ICAM-1, GMCSF, and IL-8. In the current investigation, we have reexamined the supernatants from this earlier study and now extend our observations to include IL-6 (Fig. 1)
Text-mined interactions from Literome
Huang et al., J Biol Chem 2003
:
c-Src dependent tyrosine phosphorylation of
IKKbeta is
involved in tumor necrosis factor-alpha induced
intercellular adhesion molecule-1 expression
Catley et al., Br J Pharmacol 2005
(Asthma) :
Similarly,
IKK beta ( KA ) and I kappa B alpha delta N overexpression also
inhibited IL-1beta- and TNF alpha dependent increases in
ICAM-1 , IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Uchihara et al., Int J Cancer 2006
(Hodgkin Disease) :
Coexpression of IkappaB,
IKK , NIK and TRAF dominant negative constructs with CD30
inhibited CD30 induced activation of
ICAM-1 promoter, suggesting that CD30 induces ICAM-1 via NF-kappaB signalling
Catley et al., Mol Pharmacol 2006
(Pulmonary Disease, Chronic Obstructive) :
As observed above,
ICAM-1 , IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was
reduced by the
IKK inhibitors ... As observed above,
ICAM-1 , IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was
reduced by the
IKK inhibitors
Liao et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009
:
The
IKK-2 inhibitor, SC-514, inhibited IL-1beta induced IKappaBalpha protein activity, blocked p65 nuclear translocation, caused a significant reduction in IL-1beta induced DNA binding activity for p65 and ICAM-1 mRNA expression, and
suppressed ICAM-1 expression on A549 cell surface ( all P < 0.01 )