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ANGPT2 — RAF1

Text-mined interactions from Literome

Smith et al., Endocrinology 1999 (Second Messenger Systems) : Hence, Raf-1 kinase activation by Ang II in BAG cells is dependent on Ras, is mediated in part via Gi and phosphatidylinositol 3-kinase, and is negatively regulated via Ca2+ influx and a downstream signaling element ( s )
Yogi et al., Arterioscler Thromb Vasc Biol 2007 (MAP Kinase Signaling System) : Ang II but not ET-1 induced c-Src phosphorylation in c-Src ( +/+ ) VSMCs. Activation of c-Raf , an effector of Ras, was significantly increased by ET-1 and Ang II in c-Src ( +/+ ) VSMCs. Ang II but not ET-1 mediated c-Raf phosphorylation was inhibited by c-Src deficiency
Mima et al., Diabetes 2012 (Diabetes Mellitus, Experimental...) : These results showed that the renal protective effects of GLP-1 were mediated via the inhibition of Ang II actions on cRaf ( Ser259 ) and diminished by diabetes because of PKCß activation and the increased degradation of GLP-1R in the glomerular endothelial cells
Maloney et al., Am J Physiol 1999 : ANG II-induced activations of Fyn, Raf-1 , and ERK were augmented in cells pretreated with BAPTA-AM, but ANG II-induced expression of the dual-specificity phosphatase mitogen activated protein kinase phosphatase-1 was blocked by BAPTA-AM pretreatment