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HES7 — NOTCH1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Bessho et al., Genes Cells 2001
:
Promoter analysis indicated that
Hes7 expression is
controlled by
Notch signalling
Iso et al., J Cell Physiol 2003
:
HES/E ( spl ) had been the only known
effector of
Notch signaling until a recent discovery of a related but distinct bHLH protein family, termed HERP ( HES related repressor protein, also called Hey/Hesr/HRT/CHF/gridlock )
Katoh et al., Int J Oncol 2004
:
Activation of Notch signaling pathway leads to transcriptional
activation of
Hes family genes through the interaction between
Notch intracellular domain and RBPSUH ( CSL )
King et al., Biochem Biophys Res Commun 2006
:
Hrt and
Hes negatively
regulate Notch signaling through interactions with RBP-Jkappa ... Here we show that Hrt2 and Hes1 interact with RBP-Jkappa to negatively regulate
Notch dependent activation of Hrt and
Hes expression
Taelman et al., Development 2006
:
Here, we show that the Xenopus Hairy related transcription factor ( HRT ) gene XHRT1, and the
Hairy/Enhancer of split ( HES ) genes Xhairy1, Xhairy2b, esr9 and esr10, have distinct restricted dynamic expression patterns during pronephros development, and that their expression is
regulated by
Notch
Katoh et al., Int J Oncol 2008
:
P53 induced
NOTCH1 upregulation
leads to HES1,
HES5 , HEY1, HEY2 or HEYL upregulation for the repression of tissue specific bHLH transcriptional activators
Batts et al., Hear Res 2009
:
These results indicate that the mammalian auditory epithelium retains the ability to regulate Notch signaling and
Notch dependent
Hes activity in response to cellular trauma and that the signaling is transient
Kubo et al., Development 2009
:
Interestingly, unlike other developmental contexts in which
Hes gene expression is
regulated by
Notch signaling, Hairy1 expression in the CMZ is regulated by Wnt signaling
Kageyama et al., Mol Cells 2009
:
Hes7 expression oscillates by negative feedback and is cooperatively
regulated by Fgf and
Notch signaling
Albright et al., J Pharmacol Exp Ther 2013
:
Measurements of Notch related toxicity included goblet cell metaplasia in the gut, marginal-zone depletion in the spleen, reductions in B cells, and changes in expression of the
Notch regulated
hairy and enhancer of split homolog-1 from blood cells
Kageyama et al., Wiley interdisciplinary reviews. Developmental biology 2012
:
In the mouse PSM,
Hes7 induces coupled oscillations of Notch and Fgf signaling, while
Notch and Fgf signaling cooperatively regulate Hes7 oscillation, indicating that Hes7 and Notch and Fgf signaling form the oscillator networks