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BCL6 — PRDM1
Text-mined interactions from Literome
Shaffer et al., Immunity 2000
(Inflammation) :
Since BCL-6 expression is silenced in plasma cells,
repression of
blimp-1 by
BCL-6 may control plasmacytic differentiation
Vasanwala et al., J Immunol 2002
(Cell Transformation, Neoplastic) :
We have investigated the mechanism for how
BCL-6 represses
Blimp-1 transcription, and have found that BCL-6 regulates the Blimp-1 promoter through a novel mechanism involving AP-1 elements
Klein et al., Int J Hematol 2003
(Leukemia, Plasma Cell) :
The B-cell transcription factor pax-5 is mainly responsible for a B-cell phenotype, and
bcl-6 represses the plasma cell transcription factor
blimp-1 and plasma cell differentiation
Kusam et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
We found that in primary mouse B cells,
BCL-6 repressed expression of the
Blimp-1 , p27kip1, and cyclin D2 target genes ... Our data indicate that BCL-6 may act to maintain B cells in a germinal center-like state, and
repression of
Blimp-1 by
BCL-6 may be particularly crucial for stabilization of the germinal center phenotype
Nera et al., Immunity 2006
:
Moreover, the expression of the plasma cell-characteristic transcription factors
Blimp-1 and XBP-1 were significantly upregulated and the expression of
Bcl-6 diminished in the Pax5 ( -/- ) cells, and this alteration was normalized by restored Pax5 expression
Ochiai et al., Int Immunol 2008
:
Regulation of the plasma cell transcription factor
Blimp-1 gene by Bach2 and
Bcl6
Lin et al., Leukemia 2011
(Lymphoma, B-Cell) :
We identify that, on cell adhesion to FDC, FDC induces upregulation of
PRDM1 expression through downregulation of miR-9 and let-7 families and
induces downregulation of
BCL-6 through upregulation of miR-30 family in B-lymphocytes and lymphoma cells ... We further demonstrate that the miR-30 family directly controls
BCL-6 expression and miR-9-1 and let-7a directly
control PRDM-1 expression through targeting their 3'UTR, mediating the FDC effect
Oestreich et al., Nat Immunol 2012
:
T ( H ) 1 cells increased their Bcl-6/T-bet ratio in response to limiting IL-2 conditions, which allowed excess
Bcl-6 to
repress its direct target
Prdm1 ( which encodes the transcriptional repressor Blimp-1 ) ... The
Bcl-6 dependent repression of
Blimp-1 effectively induced a partial T ( FH ) profile because Blimp-1 directly repressed a subset of T ( FH ) signature genes, including Cxcr5
Ding et al., J Immunol 2013
:
In the human PRDM1 locus, CD40L treatment enhanced the ability of STAT3 to upregulate Blimp-1 by removing
BCL6 , a potent
inhibitor of
Blimp-1 expression, from a shared BCL6/STAT3 site in intron 3