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GRAP2 — IL11
Text-mined interactions from Literome
Ling et al., Crit Care Med 2002
:
In contrast to its effects on the janus kinase/STAT pathways,
interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and
p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Scicchitano et al., Blood Cells Mol Dis 2008
(MAP Kinase Signaling System) :
In addition, these results suggest that IL-6,
IL-11 , GM-CSF, G-CSF and Activin A are similarly
regulated by
p38 and NF-kappaB and that the MEK1, JNK and PKC pathways appear to play a more limited role in modulating cytokine expression in HBMSC
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Shin et al., Carcinogenesis 2012
(Neoplasm Invasiveness) :
These results suggest that both the PI3K and Raf pathways are necessary for the expression of IL-11 in oncogenic Ras mutated cells, and that JNK,
p38 and Stat3 also
contribute to oncogenic Ras induced
IL-11 expression