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CSF1 — IL2
Text-mined interactions from Literome
Frei et al., J Neuroimmunol 1992
:
Here we report that in addition to GM-CSF, murine astrocytes also produce
macrophage (M)-CSF upon
stimulation with tumor necrosis factor alpha,
interleukin-1 and lipopolysaccharides
Schaafsma et al., Blood 1991
(Carcinoma, Renal Cell...) :
The presence of
IL-2 induced GM-CSF and
M-CSF was also demonstrated by specific radioimmunoassays
Misago et al., Int J Hematol 1993
:
Enhancing
effects of
IL-2 on
M-CSF production by human peripheral blood monocytes ... Our findings here showed that
interleukin-2 (IL-2) , at a concentration of more than 0.05 ng/ml,
led to a 12-fold increase in the production of
M-CSF in the human peripheral blood mononuclear cells after 72 h incubation compared to the control culture ... The enhancing
effect of
IL-2 on
M-CSF secretion was also observed when IL-2 stimulated non-phagocytic cell conditioned medium was added to monocyte cultures
Hamilton et al., J Leukoc Biol 1993
:
We demonstrate with elutriation purified human monocytes that, in contrast to lipopolysaccharide, recombinant human
CSF-1 does not
induce secretion of prostaglandin E2,
interleukin-6 (IL-6), IL-1 beta, or tumor necrosis factor alpha, as measured by immunoassay ; however, increased urokinase-type plasminogen activator ( u-PA ) activity in cell lysates and mRNA was observed
Brach et al., J Immunol 1993
:
Here we report that binding of human
IL-2 to its binding site
leads to transcriptional activation of the
macrophage CSF (M-CSF) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody ... Transcriptional
activation of the
M-CSF gene by
IL-2 is preceded by enhanced binding activity of the transcription factor NF-kappa B to its recognition sequence in the 5 ' regulatory enhancer region of the M-CSF gene ... Taken together, our findings indicate that
IL-2 induces gene expression of
M-CSF in human blood derived Mo and provide evidence for involvement of NF-kappa B in transcriptional regulation of this gene
Dupuis et al., Biochim Biophys Acta 1996
:
While GM-CSF ( 10 ng/ml ) and
interleukin-1 ( 10 U/ml )
stimulated M-CSF production from monocyte derived macrophages, PAF did not
Kutza et al., AIDS 1998
:
IL-2 also
increases M-CSF production and M-CSF receptor expression by human monocytes, but the subsequent effects on HIV-1 replication in MDM have yet to be determined