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EDN1 — EGFR

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EGFR → EDN1 (increases, EDN1 Activity)
  Evidence: Treatment of cells with GPCR agonists such as endothelin- 1 (ET-1), thrombin, bombesin, and lysophosphatidic acid (LPA) transactivates ErbB1 (reviewed by Zwick et al. [48]). Mechanistically, the process involves rapid stimulation of metalloproteinases followed by cleavage of an ErbB1 ligand precursor, e.g., pro-HB-EGF [49], whose binding activates ErbB1 and downstream signaling pathways
• NCI Pathway Database EGFR-dependent Endothelin signaling events: ETA receptor/Endothelin-1 complex (EDNRA-EDN1) → EGFR (EGFR) (modification, activates) Iwasaki et al., Endocrinology 1999, Cheng-Hsien et al., Pflugers Arch 2006*, Chen et al., Mol Pharmacol 2006*, Daub et al., Nature 1996, Iwasaki et al., J Cardiovasc Pharmacol 1998*
  Evidence: mutant phenotype, other species
• NCI Pathway Database EGFR-dependent Endothelin signaling events: ETA receptor/Endothelin-1 complex (EDNRA-EDN1) → EGF/EGFR complex (EGF-EGFR) (modification, activates)
  Iwasaki et al., Endocrinology 1999, Cheng-Hsien et al., Pflugers Arch 2006*, Chen et al., Mol Pharmacol 2006*, Daub et al., Nature 1996, Iwasaki et al., J Cardiovasc Pharmacol 1998*
  Evidence: mutant phenotype, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: EGFR — EDN1 (interaction, mapped from kegg_pathways mint intact)
• STRING interaction: EGFR — EDN1 (interaction, mapped from kegg_pathways mint intact)
• STRING interaction: EDN1 — EGFR (interaction, mapped from pdb)
• STRING interaction: EDN1 — EGFR (interaction, mapped from pdb)

Text-mined interactions from Literome

Cheng-Hsien et al., Pflugers Arch 2006 : Src homology 2-containing phosphotyrosine phosphatase regulates endothelin-1 induced epidermal growth factor receptor transactivation in rat renal tubular cell NRK-52E
Bien et al., Cancer Res 2007 (Cardiomyopathies) : In vitro investigations confirmed the regulation of endothelin-1 by doxorubicin and indicated that the doxorubicin mediated increase of endothelin-1 expression involves epidermal growth factor receptor signaling via the MEK1/2-ERK1/2 cascade, which was further confirmed by immunoblotting studies in the left ventricle of treated animals