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APOB — MMP1
Text-mined interactions from Literome
Huang et al., Arterioscler Thromb Vasc Biol 1999
(Arteriosclerosis) :
Oxidized
LDL stimulates
matrix metalloproteinase-1 expression in human vascular endothelial cells ... In the present study, we found that oxidized
low density lipoprotein (LDL) stimulated
MMP-1 release from both human umbilical vein and aortic endothelial cells ... We also found that oxidized
LDL markedly
stimulated MMP-1 expression in these cells and that the degree of LDL oxidation was positively correlated with the level of MMP-1 mRNA expression ... Furthermore, our data showed that stimulated MMP-1 secretion was inhibited by actinomycin D and that the nascent MMP-1 mRNA synthesis was stimulated by oxidized LDL, indicating that oxidized
LDL activated transcription of the
MMP-1 gene ... Taken together, these results have shown for the first time that oxidized
LDL stimulates
MMP-1 transcription and secretion by vascular endothelial cells, suggesting that oxidized LDL may be a potent stimulator for MMP-1 expression in atherosclerotic plaques, thus promoting plaque rupture
Huang et al., Arterioscler Thromb Vasc Biol 2000
(Arteriosclerosis) :
Because large quantities of immunoglobulin G and ICs ( ICs ), including low density lipoprotein containing ICs ( LDL-ICs ), are present in atherosclerotic lesions, we examined the
effect of
LDL-ICs on macrophage
MMP-1 expression ... With the use of ICs prepared with human LDL and rabbit anti-LDL antiserum, our enzyme linked immunosorbent assays and Northern blots showed that
MMP-1 secretion and expression by U937 histiocytes were
induced by
LDL-ICs ... Furthermore, our results showed that blocking of Fc-gamma receptor I and II ( FcgammaRI and FcgammaRII ) inhibited 70 % and 55 %, respectively, of the
LDL-IC induced secretion of
MMP-1 ... Finally, our data showed that both PD98059, an inhibitor of the mitogen activated protein kinase pathway, and Ro-31-2880, an inhibitor of protein kinase C, inhibited
LDL-IC stimulated
MMP-1 secretion in a dose dependent manner, with 96 % and 95 % inhibition, respectively, at the respective doses of 50 micromol/L and 80 nmol/L
Huang et al., Atherosclerosis 2001
:
Oxidized
LDL differentially
regulates MMP-1 and TIMP-1 expression in vascular endothelial cells
Anderson et al., Clin Immunol 2002
:
Results also showed that pretreatment of the cells with IFN-gamma augmented
LDL containing IC (LDL-IC) induced
MMP-1 secretion in a dose- and time dependent manner ... Finally, we demonstrated that PD98059 was able to block LDL-IC induced MMP-1 secretion, regardless of whether the cells were pretreated with IFN-gamma or not, suggesting that IFN-gamma pretreatment did not alter the essential role of the ERK signaling pathway in
LDL-IC induced
MMP-1 expression ... In conclusion, the present study has demonstrated that IFN-gamma pretreatment augments
LDL-IC induced
MMP-1 expression in U937 cells, thus elucidating an immune mechanism potentially involved in plaque destabilization
Ardans et al., J Leukoc Biol 2002
:
ox-LDL,
LDL , and HDL alone
had no effect on MMP-1,
MMP-9 , or TIMP-1 production ... However, in the presence of tumor necrosis factor (TNF)-alpha and GM-CSF,
ox-LDL enhanced
MMP-1 significantly by two- to threefold, increased MMP-9 slightly, and had no effect on TIMP-1 production ... In contrast, HDL suppressed the induction of
MMP-1 by TNF-alpha and GM-CSF as well as the
ox-LDL mediated
increase in MMP-1 production ... The
enhancement of
MMP-1 production by
ox-LDL occurred through, in part, a prostaglandin E2 ( PGE2 ) -dependent pathway as indomethacin suppressed and PGE2 restored MMP-1 production
Li et al., Circulation 2003
:
Ox-LDL increased the expression of
MMP-1 ( collagenase ) and MMP-3 ( stromelysin-1 ) in a concentration- and time dependent manner
Maldonado et al., Immunology 2003
:
Deletion analysis showed that
LDL-IC stimulated
MMP-1 promoter activity in cells transfected with the Construct 1 that contained a 4,334-bp MMP-1 promoter fragment, but had no effect in cells transfected with other constructs that had shorter MMP-1 promoter ( 2685-bp or less ), suggesting that cis acting elements located between -4334 and -2685 are required for the promoter stimulation ... The mutation study further indicated that the activator protein-1 (AP-1) ( -3471 ) or Ets ( -3836 ) motifs in this distal region were essential for the
LDL-IC stimulated
MMP-1 expression ... Moreover, although above deletion analysis showed that
LDL-IC did not
stimulate MMP-1 promoter activity in cells transfected with constructs that contained the proximal AP-1 ( -72 ) and Ets ( -88 ) in the promoter fragments that are 2685-bp or less, the mutations of the -72 AP-1 or the -88 Ets motif in the construct 1 abolished the stimulation of MMP-1 expression by LDL-IC, suggesting that a long promoter sequence is required for the -72 AP-1 and -88 Ets motifs to be involved in the stimulation ... In conclusion, the present study shows that both the distal and proximal AP-1 and Ets motifs are required for
LDL-IC stimulated
MMP-1 expression in U937 histiocytes
Kume et al., Nihon rinsho. Japanese journal of clinical medicine 2004
(Arteriosclerosis) :
Lectin-like oxidized LDL receptor-1 ( LOX-1 ) is a cell surface receptor for oxidized LDL, which is abundantly expressed in atherosclerotic plaques and is involved in oxidized
LDL induced
MMP production and apoptosis
Mehta et al., Cardiovasc Res 2004
:
Ox-LDL also
increased MMP-1 expression and activity, and treatment of HCAECs with aspirin decreased this effect ( P < 0.01 )
May et al., Thromb Haemost 2005
(Arteriosclerosis) :
We studied the
effect of
E-LDL on the activation of plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on
MMP activation during cellular interactions ... In VSMCs,
E-LDL induced
MMP-1 and MMP-2 secretion ... Together, enzymatical modification of
LDL allows a direct activation of
MMP expression in monocytes and VSMCs, and indirectly promotes the induction of paracrine, cytokine mediated intercellular activation processes
Chen et al., Hypertension 2005
:
Compared with untransfected cells,
ox-LDL treatment ( 50 microg/mL, 24 hours ) markedly
induced the expression of the leukocyte adhesion molecules intercellular adhesion molecule-1 ( ICAM-1 ), and vascular cell adhesion molecule-1 (VCAM)-1 as well as
matrix metalloproteinase (MMP)-1 in cells transfected with CMV-LOX-1wt ( P < 0.05 ) but not in cells transfected with CMV-LOX-1 ( 1-261 )
Zhang et al., J Leukoc Biol 2006
(Coronary Artery Disease) :
The objective of this study was to compare the individual and combined
effect of CRP and
ox-LDL on human monocyte
MMP-1 and the role of MCP-1 in this effect ...
Enhancement of
MMP-1 by CRP and
ox-LDL was attributable to a differential increase in MCP-1 and prostaglandin E2 ( PGE2 ) ... Accordingly, CRP- and
ox-LDL induced
MMP-1 production by monocytes was inhibited by anti-MCP-1 antibodies and indomethacin, respectively
Akiba et al., J Atheroscler Thromb 2007
:
Suppression of oxidized
LDL induced PDGF receptor beta activation by ginkgo biloba extract
reduces MMP-1 production in coronary smooth muscle cells
Ishikawa et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid...) :
Human RA fibroblast-like synoviocytes ( FLS ) were assessed for ox-LDL induced expression of LOX-1 and
ox-LDL induced production of
matrix metalloproteinase 1 (MMP-1) and MMP-3 ... Levels of
MMP-1 and MMP-3 were
enhanced by stimulation of RA FLS with
ox-LDL , and the production of both MMPs was inhibited by blockade of the ox-LDL-LOX-1 interaction with the anti-LOX-1 neutralizing antibody or sLOX-1