Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Kaburagi et al., Diabetologia 2001 : Insulin independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin receptor from that of IRS-1
Hemi et al., J Biol Chem 2002 (Insulin Resistance...) : Similar to TNF, cycloheximide and anisomycin stimulated serine phosphorylation of IRS-1 and IRS-2, reduced their ability to interact with the insulin receptor , inhibited the insulin induced tyrosine phosphorylation of IRS proteins, and diminished their association with phosphatidylinositol 3-kinase (PI3K)