◀ Back to RAD51
RAD51 — RPA1
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
RAD51
→
RPA1
(reaction)
Golub et al., Nucleic Acids Res 1998
-
Reactome Reaction:
RAD51
→
RPA1
(indirect_complex)
Baumann et al., J Mol Biol 1999, Masson et al., EMBO J 1999, Sehorn et al., Nature 2004, Oliver-Bonet et al., Mol Hum Reprod 2005, Thorslund et al., EMBO J 2007, Oliver-Bonet et al., Mol Hum Reprod 2007, Murayama et al., Nature 2008, Sheridan et al., Nucleic Acids Res 2008, Okorokov et al., PloS one 2010, Baumann et al., Cell 1996, Scully et al., Cell 1997, Barlow et al., EMBO J 1997, Benson et al., Nature 1998, Golub et al., Nucleic Acids Res 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RPA1
—
RAD51
(direct interaction, two hybrid)
Du et al., J Proteome Res 2009
-
IRef Biogrid Interaction:
RPA1
—
RAD51
(direct interaction, pull down)
Sugiyama et al., J Biol Chem 2002*
-
IRef Dip Interaction:
Complex of BRIP1-PALB2-BRCA2-RBBP8-RAD51-RPA1-BRCA1
(physical association, molecular sieving)
Sy et al., Proc Natl Acad Sci U S A 2009
-
IRef Dip Interaction:
RAD51
—
RPA1
(physical association, experimental interaction detection)
Golub et al., Nucleic Acids Res 1998
-
IRef Dip Interaction:
RAD51
—
RPA1
(physical association, coimmunoprecipitation)
Golub et al., Nucleic Acids Res 1998
-
IRef Hprd Interaction:
RPA1
—
RAD51
(in vitro)
Wong et al., Oncogene 2003*
-
IRef Hprd Interaction:
RPA1
—
RAD51
(in vivo)
Wong et al., Oncogene 2003*
-
IRef Hprd Interaction:
RAD51
—
RPA1
(in vitro)
Sugiyama et al., J Biol Chem 2002*, Golub et al., Nucleic Acids Res 1998
-
IRef Hprd Interaction:
RAD51
—
RPA1
(in vivo)
Sugiyama et al., J Biol Chem 2002*, Golub et al., Nucleic Acids Res 1998
-
IRef Intact Interaction:
RAD51
—
RPA1
(physical association, two hybrid)
Du et al., J Proteome Res 2009
-
IRef Ophid Interaction:
RAD51
—
RPA1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Alani et al., J Mol Biol 1992
:
In an assay that measures the pairing of circular ssDNA with homologous linear duplex DNA,
y-RPA stimulated the strand-exchange activity of Sepl approximately threefold and the activity of
RecA protein to the same extent as did E. coli SSB
Sugiyama et al., J Biol Chem 1997
:
Here, the
effects of
replication protein A (RPA) on presynaptic complex formation and DNA strand exchange activities of
Rad51 protein were examined ... With phiX174 ssDNA, the ATPase activity of
Rad51 protein is
stimulated approximately 1.4-fold by
RPA , provided that Rad51 protein is in excess of the ssDNA concentration ; otherwise, RPA inhibits ATPase activity ... In contrast, with ssDNA devoid of secondary structure ( poly ( dT ), poly ( dA ), poly ( dI ), and etheno-M13 DNA ),
RPA does not
stimulate the already elevated ATPase activity of
Rad51 protein, but inhibits activity at low Rad51 protein concentrations