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GRB2 — WAS

Pathways - manually collected, often from reviews:

• Reactome Reaction: GRB2 → WAS (direct_complex) Carlier et al., J Biol Chem 2000, Moreau et al., Nat Cell Biol 2000, Fukuoka et al., J Cell Biol 2001, Rohatgi et al., J Biol Chem 2001, Ho et al., Proc Natl Acad Sci U S A 2001, Kato et al., Biochem Biophys Res Commun 2002, Aspenström et al., Exp Cell Res 2002, Cory et al., J Biol Chem 2002, Wu et al., J Biol Chem 2004
• Reactome Reaction: GRB2 → WAS (reaction) Carlier et al., J Biol Chem 2000, Moreau et al., Nat Cell Biol 2000, Fukuoka et al., J Cell Biol 2001, Rohatgi et al., J Biol Chem 2001, Ho et al., Proc Natl Acad Sci U S A 2001, Kato et al., Biochem Biophys Res Commun 2002, Aspenström et al., Exp Cell Res 2002

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: WAS — GRB2 (physical association, affinity chromatography technology) She et al., Mol Biol Cell 1997*
• IRef Biogrid Interaction: WAS — GRB2 (direct interaction, pull down) She et al., Mol Biol Cell 1997*
• IRef Biogrid Interaction: WAS — GRB2 (direct interaction, pull down) Banin et al., Curr Biol 1996*
• IRef Hprd Interaction: WAS — GRB2 (in vivo) O'Sullivan et al., Int J Biochem Cell Biol 1999*, She et al., Mol Biol Cell 1997*
• IRef Ophid Interaction: GRB2 — WAS (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kempiak et al., J Biol Chem 2005 : Here we show that the actin polymerization is dependent upon activation of the Arp2/3 complex by neural Wiskott-Aldrich Syndrome protein ( N-WASP ) via Grb2 and Nck2
Miki et al., Cell Growth Differ 1997 (Wiskott-Aldrich Syndrome) : Because WASP also binds to Ash/Grb2 SH3 domains and the association of Ash/Grb2 and Shc is induced by 12-O-tetradecanoylphorbol 13-acetate treatment, a signaling pathway, PKC-tyrosine kinase-Shc-Ash/Grb2-WASP, is suggested for regulating megakaryocyte differentiation
She et al., Mol Biol Cell 1997 (Wiskott-Aldrich Syndrome) : Purified glutathione S-transferase-full-length-Grb2 fusion protein, but not the individual domains of Grb2, enhances the association of WASp with the EGFR, suggesting that Grb2 mediates the association of WASp with EGFR