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HDAC1 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(direct interaction, pull down)
Luo et al., Nature 2000
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(direct interaction, enzymatic study)
Juan et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Murphy et al., Genes Dev 1999*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Insinga et al., EMBO J 2004*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Sun et al., J Biol Chem 2007
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Yu et al., Exp Cell Res 2010*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Sinha et al., EMBO J 2010*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Li et al., Cancer Lett 2012*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Di Agostino et al., Cancer Cell 2006
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Ito et al., EMBO J 2002*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Lei et al., Cancer Cell 2006*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Jin et al., J Biol Chem 2008
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Wu et al., Oncogene 2001*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Juan et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(direct interaction, pull down)
Juan et al., J Biol Chem 2000*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Dohi et al., Nature structural & molecular biology 2008*
-
IRef Biogrid Interaction:
HDAC1
—
TP53
(physical association, affinity chromatography technology)
Wang et al., EMBO J 2005*
-
IRef Dip Interaction:
Complex of HDAC1-BHLHE40-TP53
(anti bait coimmunoprecipitation)
Qian et al., Proc Natl Acad Sci U S A 2012*
-
IRef Hprd Interaction:
TP53
—
HDAC1
(in vivo)
Juan et al., J Biol Chem 2000*, Di Agostino et al., Cancer Cell 2006
-
IRef Hprd Interaction:
TP53
—
HDAC1
(in vitro)
Juan et al., J Biol Chem 2000*, Di Agostino et al., Cancer Cell 2006
-
IRef Intact Interaction:
Complex of NFYA-KAT2B-TP53-HDAC1
(association, anti bait coimmunoprecipitation)
Di Agostino et al., Cancer Cell 2006
-
IRef Intact Interaction:
Complex of HDAC1-NFYA-TP53
(association, anti bait coimmunoprecipitation)
Di Agostino et al., Cancer Cell 2006
-
IRef Intact Interaction:
HDAC1
—
TP53
(physical association, anti bait coimmunoprecipitation)
Di Agostino et al., Cancer Cell 2006
-
IRef Intact Interaction:
HDAC1
—
TP53
(physical association, anti bait coimmunoprecipitation)
Sinha et al., EMBO J 2010*
-
IRef Intact Interaction:
Complex of BANP-TP53-HDAC1
(association, anti bait coimmunoprecipitation)
Sinha et al., EMBO J 2010*
Text-mined interactions from Literome
Juan et al., J Biol Chem 2000
:
Down-regulation of
p53 activity by HDACs is
HDAC dosage
dependent , requires the deacetylase activity of HDACs, and depends on the region of p53 that is acetylated by p300/CREB binding protein (CBP)
Luo et al., Nature 2000
:
PID specifically interacts with p53 both in vitro and in vivo, and its expression
reduces significantly the steady-state levels of acetylated
p53
Koumenis et al., Mol Cell Biol 2001
(Cell Transformation, Neoplastic) :
At the molecular level, DNA damage
induces the interaction of
p53 with the transcriptional activator p300 as well as with the transcriptional corepressor
mSin3A ... In contrast, hypoxia primarily
induces an interaction of
p53 with
mSin3A , but not with p300
Imanishi et al., J Clin Endocrinol Metab 2002
(Thyroid Neoplasms) :
Western blot analysis demonstrated that the
HDAC-1 increased the expression of acetylated histones, as well as of p21 ( cip1/waf1 ), but did not
affect levels of total histone and endogenous
p53
Zeng et al., J Biol Chem 2003
:
Laminar flow
increased the activity of histone deacetylase (HDAC) and the association of
p53 with
HDAC1
Rocha et al., Mol Cell Biol 2003
:
p53 represses cyclin D1 transcription through down regulation of Bcl-3 and
inducing increased association of the p52 NF-kappaB subunit with
histone deacetylase 1 ... Concomitant with this,
p53 induced a significant increase in the association of p52 and
histone deacetylase 1 (HDAC1)
Wilkinson et al., Mol Cell Biol 2005
:
p53 promotes SnoN and
histone deacetylase interaction at an overlapping Smad binding, p53 regulatory element ( SBE/p53RE ) in AFP
Peltonen et al., Pigment Cell Res 2005
(Melanoma) :
Inhibiting p53 function by a dominant negative p53 ( p53 ( 175His ) ) confirmed that the
HDAC inhibitor induced apoptosis was
independent of wild-type
p53 , even though TSA slightly activated p53 in a reporter assay
Shetty et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Indeed,
HDAC inhibitors
activate NF-kappaB and
p53 and upregulate DR5 expression
Blagosklonny et al., Cancer Res 2005
:
We suggest that, by either restoring or mimicking p53 trans-functions,
histone deacetylase inhibitors
initiate degradation of mutant
p53
Tsuyama et al., Biochem Biophys Res Commun 2005
(Multiple Myeloma) :
Expression of
p53 , a direct target gene of Bcl6, was downregulated in the IL-6 stimulated cells, and this process was
impaired by an
HDAC inhibitor
Wang et al., Biol Pharm Bull 2005
:
The activated human
HDAC1 significantly
induced the expression levels of mRNA for
p53 , PPAR-gamma and Bak and reduced the p21 expression level compared with the levels in control littermates
Calonghi et al., Biochim Biophys Acta 2007
(Osteosarcoma) :
In particular hyperacetylation of
p53 induced by the
HDAC1 inhibitory activity of 9-HSA has been demonstrated to increase Bax synthesis both at the transcriptional and the translational level
Huang et al., Nature 2007
:
p53 is
regulated by the lysine demethylase
LSD1
Xu et al., J Biol Chem 2007
:
The activity of
p53 is differentially
regulated by Brm- and Brg1 containing
SWI/SNF chromatin remodeling complexes
Zhang et al., Cancer Lett 2008
(Carcinoma, Hepatocellular...) :
Researches have shown that
ING2 can
activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
Chang et al., J Virol 2008
:
Critical
role of
p53 in
histone deacetylase inhibitor induced Epstein-Barr virus Zta expression
Chen et al., EMBO J 2010
:
MDM2 also
inhibits p53 transcriptional activity by recruiting
histone deacetylase and corepressors to p53
LeBoeuf et al., Dev Cell 2010
:
Mutant embryos display increased levels of acetylated
p53 , which opposes p63 functions, and p53 is
required for
HDAC inhibitor mediated p21 expression in keratinocytes ... Our data identify critical requirements for HDAC1/2 in epidermal development and indicate that
HDAC1/2 directly mediate repressive functions of p63 and
suppress p53 activity
Zeng et al., Cancer Res 2011
:
We show that
p53 is
required for both
HDAC and PcG to repress Arf expression
Cellai et al., J Cell Mol Med 2012
(Leukemia, Myeloid, Acute) :
Moreover, novel HDACi prompted
p53 and a-tubulin acetylation and, consistently,
inhibited HDAC1 and 6 activity
Huang et al., Evidence-based complementary and alternative medicine : eCAM 2012
:
On the other hand, we found that
NBM-HD-1 increased the expressions of tumor-suppressor gene
p53 in a dose dependent manner
McCormack et al., Leukemia 2012
(Leukemia, Myeloid, Acute) :
Our results suggest the concomitant targeting of
MDM2-p53 and
HDAC inhibition , may be an effective therapeutic strategy for the treatment of AML
Li et al., Cancer Lett 2012
(Bone Neoplasms...) :
Overexpression of
HDAC1 also significantly
inhibited p53 transcriptional activity ... Pharmacologic inhibitor of
HDAC , trichostatin A (TSA)
promoted p53-p300 interaction and recruitment of p53 Lys-382 to promoter regions of its target genes p21 and Puma, consequently inducing apoptosis and stabilizing the acetylation of p53 at Lys-382 together with the upregulation of p21 and Puma, which were impaired in EFTs cells after the knockdown of p53 expression
Yan et al., Oncogene 2013
:
Here we found that
histone deacetylase (HDAC) inhibitors
suppress both wild-type and mutant
p53 transcription in time- and dose dependent manners
Mizuguchi et al., BMC molecular biology 2012
:
Up-regulation of SPRR2A, similar to that seen during barrier epithelia wound repair responses reduces p53 acetylation by interfering with
p300-p53 interactions and by
increasing HDAC1 expression
Madapura et al., Cell cycle (Georgetown, Tex.) 2012
:
Modifying
p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was
sufficient to upregulate
SAP expression, indicating that SAP is a target of p53 in T cells
Jin et al., J Biol Chem 2013
(Liver Neoplasms) :
Transcriptional and translational regulation of
C/EBPß-HDAC1 protein complexes
controls different levels of
p53 , SIRT1, and PGC1a proteins at the early and late stages of liver cancer