Gene interactions and pathways from curated databases and text-mining

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HDAC1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Juan et al., J Biol Chem 2000 : Down-regulation of p53 activity by HDACs is HDAC dosage dependent , requires the deacetylase activity of HDACs, and depends on the region of p53 that is acetylated by p300/CREB binding protein (CBP)
Luo et al., Nature 2000 : PID specifically interacts with p53 both in vitro and in vivo, and its expression reduces significantly the steady-state levels of acetylated p53
Koumenis et al., Mol Cell Biol 2001 (Cell Transformation, Neoplastic) : At the molecular level, DNA damage induces the interaction of p53 with the transcriptional activator p300 as well as with the transcriptional corepressor mSin3A ... In contrast, hypoxia primarily induces an interaction of p53 with mSin3A , but not with p300
Imanishi et al., J Clin Endocrinol Metab 2002 (Thyroid Neoplasms) : Western blot analysis demonstrated that the HDAC-1 increased the expression of acetylated histones, as well as of p21 ( cip1/waf1 ), but did not affect levels of total histone and endogenous p53
Zeng et al., J Biol Chem 2003 : Laminar flow increased the activity of histone deacetylase (HDAC) and the association of p53 with HDAC1
Rocha et al., Mol Cell Biol 2003 : p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1 ... Concomitant with this, p53 induced a significant increase in the association of p52 and histone deacetylase 1 (HDAC1)
Wilkinson et al., Mol Cell Biol 2005 : p53 promotes SnoN and histone deacetylase interaction at an overlapping Smad binding, p53 regulatory element ( SBE/p53RE ) in AFP
Peltonen et al., Pigment Cell Res 2005 (Melanoma) : Inhibiting p53 function by a dominant negative p53 ( p53 ( 175His ) ) confirmed that the HDAC inhibitor induced apoptosis was independent of wild-type p53 , even though TSA slightly activated p53 in a reporter assay
Shetty et al., Mol Cell Biol 2005 (Breast Neoplasms) : Indeed, HDAC inhibitors activate NF-kappaB and p53 and upregulate DR5 expression
Blagosklonny et al., Cancer Res 2005 : We suggest that, by either restoring or mimicking p53 trans-functions, histone deacetylase inhibitors initiate degradation of mutant p53
Tsuyama et al., Biochem Biophys Res Commun 2005 (Multiple Myeloma) : Expression of p53 , a direct target gene of Bcl6, was downregulated in the IL-6 stimulated cells, and this process was impaired by an HDAC inhibitor
Wang et al., Biol Pharm Bull 2005 : The activated human HDAC1 significantly induced the expression levels of mRNA for p53 , PPAR-gamma and Bak and reduced the p21 expression level compared with the levels in control littermates
Calonghi et al., Biochim Biophys Acta 2007 (Osteosarcoma) : In particular hyperacetylation of p53 induced by the HDAC1 inhibitory activity of 9-HSA has been demonstrated to increase Bax synthesis both at the transcriptional and the translational level
Huang et al., Nature 2007 : p53 is regulated by the lysine demethylase LSD1
Xu et al., J Biol Chem 2007 : The activity of p53 is differentially regulated by Brm- and Brg1 containing SWI/SNF chromatin remodeling complexes
Zhang et al., Cancer Lett 2008 (Carcinoma, Hepatocellular...) : Researches have shown that ING2 can activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
Chang et al., J Virol 2008 : Critical role of p53 in histone deacetylase inhibitor induced Epstein-Barr virus Zta expression
Chen et al., EMBO J 2010 : MDM2 also inhibits p53 transcriptional activity by recruiting histone deacetylase and corepressors to p53
LeBoeuf et al., Dev Cell 2010 : Mutant embryos display increased levels of acetylated p53 , which opposes p63 functions, and p53 is required for HDAC inhibitor mediated p21 expression in keratinocytes ... Our data identify critical requirements for HDAC1/2 in epidermal development and indicate that HDAC1/2 directly mediate repressive functions of p63 and suppress p53 activity
Zeng et al., Cancer Res 2011 : We show that p53 is required for both HDAC and PcG to repress Arf expression
Cellai et al., J Cell Mol Med 2012 (Leukemia, Myeloid, Acute) : Moreover, novel HDACi prompted p53 and a-tubulin acetylation and, consistently, inhibited HDAC1 and 6 activity
Huang et al., Evidence-based complementary and alternative medicine : eCAM 2012 : On the other hand, we found that NBM-HD-1 increased the expressions of tumor-suppressor gene p53 in a dose dependent manner
McCormack et al., Leukemia 2012 (Leukemia, Myeloid, Acute) : Our results suggest the concomitant targeting of MDM2-p53 and HDAC inhibition , may be an effective therapeutic strategy for the treatment of AML
Li et al., Cancer Lett 2012 (Bone Neoplasms...) : Overexpression of HDAC1 also significantly inhibited p53 transcriptional activity ... Pharmacologic inhibitor of HDAC , trichostatin A (TSA) promoted p53-p300 interaction and recruitment of p53 Lys-382 to promoter regions of its target genes p21 and Puma, consequently inducing apoptosis and stabilizing the acetylation of p53 at Lys-382 together with the upregulation of p21 and Puma, which were impaired in EFTs cells after the knockdown of p53 expression
Yan et al., Oncogene 2013 : Here we found that histone deacetylase (HDAC) inhibitors suppress both wild-type and mutant p53 transcription in time- and dose dependent manners
Mizuguchi et al., BMC molecular biology 2012 : Up-regulation of SPRR2A, similar to that seen during barrier epithelia wound repair responses reduces p53 acetylation by interfering with p300-p53 interactions and by increasing HDAC1 expression
Madapura et al., Cell cycle (Georgetown, Tex.) 2012 : Modifying p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was sufficient to upregulate SAP expression, indicating that SAP is a target of p53 in T cells
Jin et al., J Biol Chem 2013 (Liver Neoplasms) : Transcriptional and translational regulation of C/EBPß-HDAC1 protein complexes controls different levels of p53 , SIRT1, and PGC1a proteins at the early and late stages of liver cancer