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AGT — HNRNPF
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Lo et al., Diabetes 2012
(Diabetes Mellitus, Experimental...) :
The results showed that
hnRNP F overexpression attenuated systemic hypertension, suppressed Agt and transforming growth factor-ß1 ( TGF-ß1 ) gene expression, and
reduced urinary
Agt and angiotensin II levels, renal hypertrophy, and glomerulotubular fibrosis in Akita hnRNP F-Tg mice ... In vitro,
hnRNP F overexpression
prevented the high-glucose stimulation of
Agt and TGF-ß1 mRNA expression and cellular hypertrophy in RPTCs
Abdo et al., Diabetologia 2013
:
In vitro, insulin inhibited Agt but stimulated
Hnrnpf and Hnrnpk expression in high-glucose media via p44/42 mitogen activated protein kinase signalling in RPTCs. Transfection with Hnrnpf or Hnrnpk small interfering RNAs
prevented insulin inhibition of
Agt expression in RPTCs