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CDH2 — WNT2
Text-mined interactions from Literome
Stewart et al., J Biol Chem 2000
:
These results indicate that the level of
cadherin-6 , but not that of E-cadherin, is strictly regulated post-translationally in
response to
Wnt signaling, and that E-cadherin and cadherin-6 may contribute different properties to cell-cell adhesion and the epithelial phenotype
Rodríguez-Esteban et al., Development 2001
:
Both the adhesion protein
N-cadherin and PKI ( an endogenous protein kinase A inhibitor ) are localized to the right side of the node and may
contribute to restrict Nodal activation by
Wnt signaling and PKA to the left side of the node
Ohira et al., Proc Natl Acad Sci U S A 2003
(Lung Neoplasms) :
Drosophila
DE-cadherin is
regulated by
Wnt/beta-catenin signaling, although this has not been demonstrated in mammalian cells
Brembeck et al., Genes Dev 2004
:
beta-Catenin controls both
cadherin mediated cell adhesion and activation of
Wnt target genes
Obara et al., Methods Mol Biol 2006
(Cell Transformation, Neoplastic) :
beta-catenin seems to link
cadherin mediated cell-cell adhesion and
Wnt signaling
Sarrió et al., Hum Pathol 2006
(Adenocarcinoma...) :
Alterations in the
cadherin-catenin expression and
activation of the
Wnt signaling have been related to the pathology of ovarian carcinomas
Kreslova et al., Genesis 2007
(Choristoma...) :
beta-Catenin plays a key role in
cadherin mediated cell adhesion as well as in canonical
Wnt signaling
Haÿ et al., Mol Cell Biol 2009
:
We show here a novel mechanism by which the adhesion molecule
N-cadherin interacts with the Wnt coreceptor LRP5 and
regulates canonical
Wnt/beta-catenin signaling in osteoblasts ... These data indicate that a previously unrecognized
N-cadherin-axin-LRP5 interaction negatively
regulates Wnt/beta-catenin signaling and is critical in the regulation of osteoblast function, bone formation, and bone mass
Nygren et al., Exp Hematol 2009
(Leukemia, B-Cell...) :
beta-catenin is involved in
N-cadherin dependent adhesion, but not in canonical
Wnt signaling in E2A-PBX1 positive B acute lymphoblastic leukemia cells
Heuberger et al., Cold Spring Harbor perspectives in biology 2010
:
Interplay of
cadherin mediated cell adhesion and canonical
Wnt signaling ... beta-Catenin is an essential molecule both in
cadherin mediated cell adhesion and in canonical
Wnt signaling
Chalpe et al., Cell Adh Migr 2010
:
This project was initiated to investigate the
role of canonical
Wnt signaling in the expression of
cadherin-7 and cadherin-11 by treating neural crest cells with Wnt3a ligand
Kim et al., Biomaterials 2010
:
It was found that cell aggregation was promoted on this surface, supporting the notion that an increase in
N-cadherin mediated cell-cell contacts and
Wnt signaling regulate hMSC differentiation into cardiomyocyte-like cells
Xu et al., J Biol Chem 2011
:
To further explore the molecular mechanism of this regulation, the roles of ß-catenin, an essential molecule in both
cadherin mediated cell adhesion and canonical
Wnt signaling, were investigated
Howard et al., PloS one 2011
(Wnt Signaling Pathway) :
A positive
role of
cadherin in
Wnt/ß-catenin signalling during epithelial-mesenchymal transition
Haÿ et al., J Bone Miner Res 2012
(Wnt Signaling Pathway) :
Peptide based mediated disruption of
N-cadherin-LRP5/6 interaction
promotes Wnt signaling and bone formation ... We also show that the peptide mediated disruption of
N-cadherin-LRP5/6 interaction
increases Wnt/ß-catenin signaling and osteoblast function in vitro and promotes calvaria bone formation in vivo
Sengupta et al., J Cell Sci 2013
:
Transfection of hypoglycosylated E-cadherin mutant, V13, but not fully N-glycosylated
E-cadherin , into sparse cells
inhibited canonical
Wnt activity by depleting nuclear ß- and ?-catenins
Grossmann et al., Science signaling 2013
(Melanoma...) :
We found that in melanoma cells,
WNT5A stimulated the disruption of
N-cadherin and ß-catenin complexes by activating the guanosine triphosphatase adenosine diphosphate ribosylation factor 6 ( ARF6 )
Hadeball et al., Mech Dev 1998
:
Xenopus
cadherin-11 ( Xcadherin-11 ) expression
requires the
Wg/Wnt signal