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GRAP2 — MAP3K7
Text-mined interactions from Literome
Cheung et al., EMBO J 2003
:
Our results suggest that TAB1 participates in a
SAPK2a/p38alpha mediated feedback control of
TAK1 , which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other signalling pathways that lie downstream of TAK1 ( JNK and IKK )
Suzuki et al., J Biol Chem 2007
(Cell Transformation, Viral...) :
On the other hand, JNK and
p38 mitogen activated protein kinases were
activated by
TAK1
Tang et al., J Exp Med 2008
(Bone Marrow Diseases...) :
Activation of
TAK1 by proinflammatory cytokines and T and B cell receptors
induces the nuclear localization of nuclear factor kappaB (NF-kappaB) and the activation of c-Jun N-terminal kinase (JNK)/AP1 and
P38 , which play important roles in mediating inflammation, immune responses, T and B cell activation, and epithelial cell survival
Tran et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
Overexpression of
TAK1 or ASK1 in Cdo ( -/- ) myoblasts and Cdo depleted C2C12 cells
restored p38MAPK activation as well as myotube formation