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PTPN1 — TNF

Text-mined interactions from Literome

Zabolotny et al., J Biol Chem 2008 (Diabetes Mellitus...) : We find that adipose tissue inflammation and the pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) regulate PTP1B expression in vivo ... Actinomycin D treatment blocked, and high dose salicylate treatment inhibited by 80 %, TNFalpha induced PTP1B expression in adipocyte cell lines, suggesting TNFalpha may induce PTP1B transcription via nuclear factor kappaB (NFkappaB) activation ... In mice with diet induced obesity, TNFalpha deficiency also partly blocked PTP1B overexpression in adipose tissue
Wu et al., J Endocrinol Invest 2012 : Rosiglitazone attenuates tumor necrosis factor-a induced protein-tyrosine phosphatase-1B production in HepG2 cells ... The underlying molecular mechanism by which TNF-a regulates hepatic protein-tyrosine phosphatase (PTP)-1B expression is not well understood ... However, its effect on TNF-a induced PTP-1B expression remains to be explored ... In the present study, we sought to identify the mechanism of TNF-a regulated hepatic PTP-1B expression and evaluate the effect of rosiglitazone on TNF-a induced hepatic PTP-1B upregulation ... Rosiglitazone significantly blocks TNF-a induced PTP-1B upregulation and NF-?B activation ... Our data strongly suggest that TNF-a induced PTP-1B overexpression may contribute to hepatic IR in obesity and diabetes, and NF-?B is involved in rosiglitazone attenuated PTP- 1B upregulation by TNF-a