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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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EPO — NFKB1

Text-mined interactions from Literome

La Ferla et al., FASEB J 2002 : Thus, both GATA-2 and NF-kappaB seem to be involved in the suppression of Epo gene expression by IL-1beta and TNF-alpha in vitro and may be responsible for impaired Epo synthesis in inflammatory diseases in vivo
Andrassy et al., Clin Nephrol 2002 (Anemia...) : Erythropoietin mediated decrease of the redox-sensitive transcription factor NF-kappaB is inversely correlated with the hemoglobin level ... The aim of this study was to determine the effect of rh-EPO on the redox-sensitive transcription factor ( NF-kappaB ) in vivo and in vitro ... In vitro studies showed that rh-EPO did not directly affect NF-KB binding activity in THP-1 cells
Figueroa et al., Exp Hematol 2002 (Anoxia) : NF-kappaB plays a key role in hypoxia-inducible factor-1 regulated erythropoietin gene expression ... We propose a key role for NF-kappaB in EPO gene regulation in response to hypoxia
Carvalho et al., Oncogene 2005 (Carcinoma, Renal Cell...) : EPO lost its death facilitating effects in the presence of an NF-kappaB inhibitor, underscoring the cause-effect relationship between EPO mediated chemosensitization and NF-kappaB inhibition
Sola et al., Pediatr Res 2005 (Brain Ischemia...) : The most effective dose after FCI was 1000 U/kg for 3 d. Immunoanalyses showed that Epo induced a significant increase in phosphorylated Janus kinase 2 and signal transducer and activator of transcription-5 expressions at 1 and 3 d and up-regulated Bcl-xL expression by 24 h after FCI but did not affect Epo receptor or NF-kappaB expression
Chong et al., Curr Neurovasc Res 2005 (Alzheimer Disease...) : Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity
Zhande et al., Am J Physiol Heart Circ Physiol 2007 : EPO caused a prolonged activation of nuclear factor (NF)-kappaB , which was blocked by inhibition of PI3K, but not by inhibition of mitogen activated protein ( MAP ) /ERK kinase ( MEK ), suggesting that EPO activated NF-kappaB requires PI3K activity