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RUNX2 — TGFB1

Text-mined interactions from Literome

Lee et al., J Cell Biochem 1999 : Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation ... TGF-beta1 treatment effectively suppressed myogenesis and induced Cbfa1 expression but was insufficient to support osteoblast differentiation reflected by the absence of ALP, OPN, and OCN
Lee et al., Mol Cell Biol 2000 : We identified Runx2/PEBP2alphaA/Cbfa1 , a global regulator of osteogenesis, as a major TGF-beta1-responsive element binding protein induced by TGF-beta1 and BMP-2 in C2C12 cells ... Consistent with the observation that Runx2 can be induced by either TGF-beta1 or BMP-2, the exogenous expression of Runx2 mediated some of the effects of TGF-beta1 and BMP-2 but not osteoblast-specific gene expression
Lee et al., Oncogene 2002 (MAP Kinase Signaling System) : Furthermore, not only the Smad pathway but also the mitogen activated protein kinase ( MAPK ) cascades are involved in the induction of Runx2 by TGF-beta1 and BMP-2
Sowa et al., J Biol Chem 2004 : In the osteoblast MC3T3-E1 cells, transforming growth factor-beta and its signaling molecule, Smad3, negatively regulated Runx2 transcriptional activity
Takagi et al., J Mol Histol 2004 : Effects of bone morphogenetic protein-2 and transforming growth factor beta1 on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastic cells ... The present study, using Northern blot and real-time reverse transcription polymerase chain reaction analyses, investigated the effects of bone morphogenetic protein-2 (BMP-2) and TGF-beta1 on mRNA expression of AJ18 and Runx2 in a clonal osteoblast precursor cell line ROB-C26 ( C26 ) cultured for 3, 6 or 9 days in the presence or absence of BMP-2
Kanaan et al., Med Sci Monit 2006 : In MC3T3-E1 osteoblast-like cell line TGF beta1 inhibited the expression of the Runx2 and osteocalcin osteoblast differentiation markers
Kwok et al., J Cell Biochem 2009 : Thus, our results suggest that TGF-beta1-inhibition of osteoblast differentiation is dependent on the MAPK pathway and this effect is most likely mediated by post-translational modification of Runx2 such as phosphorylation rather than other regulatory mechanisms
Wang et al., Nephron. Experimental nephrology 2010 : Second, TGF-beta(1) could induce increased expression of osteoblast-specific transcription factor Cbfa1 and osteogenic molecule in VSMCs. Third, the TGF-beta(1) neutralization antibody largely attenuated the upregulation of Cbfa1 and bone matrix in high-phosphate stimulated cells
Georges et al., Int J Oncol 2010 (Adenocarcinoma...) : Whereas TGF-beta1 induced over-expression of OPN and Runx2 in hepatocytes, it did not exert the same effect on hepatocytes co-cultured with CC531 cells, indicating that this response was abrogated by CC531 cells