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CDH1 — SMAD3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Phanish et al., Biochem J 2006
:
TGFbeta1 induced increases in CTGF and decreases in
E-cadherin expression were
Smad3 dependent , whereas increases in MMP-2 expression were Smad2 dependent
Medici et al., Mol Biol Cell 2006
:
However, our results also demonstrate that a complete loss of
E-cadherin and transformation to the mesenchymal phenotype are
dependent on
Smad signaling, which subsequently stimulates formation of beta-catenin/LEF-1 complexes that induce EMT
Kolosova et al., J Cell Physiol 2011
:
However, neither
Smad2/3 nor p38 MAPK were
required for the down-regulation of
E-cadherin , yet p38 MAPK was associated with fibronectin up-regulation ... However, neither
Smad2/3 nor p38 MAPK were
required for the down-regulation of
E-cadherin , yet p38 MAPK was associated with fibronectin up-regulation
Li et al., Mol Cancer Res 2010
(Colorectal Neoplasms...) :
Upregulation of vimentin, slug, snail, downregulation of
E-cadherin and
activation of
receptor-Smad3 phosphorylation were observed in M5 and MDCK cells induced by TGF-ß, whereas altered expression of these markers was not obvious in FMNL2 depleting M5 cells
Ahn et al., Oncogene 2012
(Stomach Neoplasms) :
Smad3 regulates
E-cadherin via miRNA-200 pathway