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ADRB2 — GRK4
Pathways - manually collected, often from reviews:
-
KEGG Endocytosis:
ADRBK1/ADRBK2/GRK1/GRK4/GRK5/GRK6/GRK7
→
ADRB1/ADRB2/ADRB3/CCR5/CXCR1/CXCR2/CXCR4/F2R
(protein-protein, phosphorylation)
Text-mined interactions from Literome
Mak et al., Eur J Pharmacol 2002
(Cystic Fibrosis...) :
These data suggest that the increase in
GRK activity may be one of the mechanisms underlying alterations in the coupling between beta2-adrenoceptor and adenylyl cyclase via G-protein and may thus
contribute to the downregulation of
beta2-adrenoceptor in cystic fibrosis lung
Mak et al., Br J Pharmacol 2002
:
In light of data obtained in this study, we propose that both the decrease in AC activity and the increase in
GRK activity, which are reversed by dexamethasone, may
underlie beta(2)-adrenoceptor desensitization
Freeman et al., Biochemistry 2002
:
Beta 2-adrenergic receptor stimulated ,
G protein coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2
Bawa et al., Br J Pharmacol 2003
:
Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by
beta 2-adrenoceptor dependent
GRK3 up-regulation