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CTTN — EGFR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 168 proteins Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003

Text-mined interactions from Literome

Head et al., Mol Biol Cell 2003 : Phosphorylation of cortactin tyrosine 421 and 466 was elevated in response to Src, epidermal growth factor receptor and Rac1 activation , and tyrosine 421 phosphorylated cortactin localized with F-actin in lamellipodia and podosomes
Timpson et al., Cancer Res 2005 (MAP Kinase Signaling System) : However, in this study, we show that overexpression of cortactin in HeLa cells markedly inhibits ligand induced down-regulation of the EGFR
van Rossum et al., Breast Cancer Res 2005 (Carcinoma...) : Cortactin also participates in receptor mediated endocytosis, and recent findings have shown that, during receptor internalization, cortactin overexpression inhibits the ubiquitylation mediated degradation of the epidermal growth factor receptor , resulting in a sustained ligand induced epidermal growth factor receptor activity
Timpson et al., Cancer Res 2007 (Carcinoma, Squamous Cell...) : Previously, we identified a novel role for cortactin in cancer cells, whereby cortactin overexpression attenuated ligand induced down-regulation of the epidermal growth factor (EGF) receptor ( EGFR ), leading to sustained signaling
Fantozzi et al., Acta Oncol 2008 (Carcinoma, Squamous Cell...) : It has been suggested that cortactin overexpression may increase EGFR levels in these tumors by affecting receptor downregulation, however we recently found by multivariate analysis, that cortactin expression status remained an independent prognostic factor for local recurrence, disease-free survival, and overall survival