Miller et al., Audiol Neurootol 2003
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Noise exposure induces the formation in the cochlea of 8-isoprostaglandin F ( 2alpha ) ( 8-iso-PGF ( 2alpha ) ), a marker for reactive oxygen species [ Ohinata et al., 2000a ] and a potent vasoconstrictor, raising the possibility that 8-iso-PGF ( 2alpha ) may be responsible for noise induced reductions in cochlear blood flow (CBF) ... Local 8-iso-PGF ( 2alpha ) induced a clear reduction in CBF Pickard et al., Eur J Pharmacol 1977
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Both PGF2alpha and PGE2 ( 10 ( -7 ) and 10 ( -6 ) g/kg/min ) reduced both CBF and CMRO2 ... Hence, both PGE2 and PGF2alpha reduce CBF and CMRO2, whilst PGE2 greatly increases extracranial blood flow