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EIF4E — VEGFA

Text-mined interactions from Literome

Crew et al., Br J Cancer 2000 (Carcinoma, Transitional Cell...) : The study demonstrates that eIF-4E may be involved in translational regulation of VEGF in bladder cancer and might have a role as a prognostic factor in bladder cancer
Tao et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2004 (Laryngeal Neoplasms) : The protein expression of eIF4E , eIF4G, bFGF and VEGF were significantly inhibited by elemene ; and the mRNA expression of bFGF and VEGF were inhibited either
Oridate et al., Cancer Biol Ther 2005 (Carcinoma, Squamous Cell...) : siRNA mediated decrease of eIF4E has led to decreases in the expression of CCND1, basic fibroblast growth factor and vascular endothelial growth factor
Mariappan et al., J Biol Chem 2005 : VEGF stimulated phosphorylation of Mnk1 and eIF4E and induced Mnk1 to shift from the cytoplasm to the nucleus upon phosphorylation ... VEGF induced phosphorylation of Mnk1 and eIF4E required phosphorylation of PLCgamma, c-Src, and Erk ... VEGF also stimulates Erk dependent phosphorylation of Mnk1 and eIF4E , crucial events in the initiation phase of protein translation
Dong et al., Breast Cancer Res Treat 2009 (Breast Neoplasms) : The downregulation of eIF4E expression significantly reduced the levels of VEGF , FGF-2 and cyclinD1 expression, suppressed cell growth, induced cell cycle arrest in G ( 0 ) /G ( 1 ) phase and subsequent apoptosis by activating caspase 3 in MCF-7 cells
Chang et al., Cancer Gene Ther 2013 : Reduction of eIF4E by overexpression of 4E-BP1 resulted in suppression of cap dependent protein expression of basic fibroblast growth factor ( bFGF or FGF-2 ) and vascular endothelial growth factor ( VEGF )