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EPAS1 — TIE1

Text-mined interactions from Literome

Takeda et al., Circ Res 2004 : In conclusion, EPAS1 promotes Flt-1 gene expression and induces mRNA expression of VEGF, Flk-1, and Tie2 , leading to enhancement of mature angiogenesis in vivo
Duan et al., Circulation 2005 (Anoxia) : Furthermore, we found that Tie-2 expression was significantly reduced in Hif-2alpha-/- mutants but was restored by Hif-2alpha cDNA expression ... These data demonstrate an intrinsic requirement for Hif-2alpha by endothelial cells and imply that hypoxia may control endothelial functions directly via Hif-2alpha regulated Tie-2 expression