◀ Back to IRF6

IRF6 — SERPINE1

Text-mined interactions from Literome

Ruan et al., J Vasc Res 2001 (Shock, Septic) : Anisodamine dose-dependently inhibited this LPS induced upregulation of PAI-1 and TF ... Thus, we provide evidence that anisodamine counteracts endothelial cell activation by inhibiting LPS induced PAI-1 and TF expression in these cells
Ruan et al., J Tongji Med Univ 2001 : The results showed that ligustrazini inhibited both basal and LPS induced PAI-1 mRNA expression in EC ... The effect of ligustrazini on LPS induced PAI-1 secretion worked in a dose dependent manner
Song et al., Chin Med J (Engl) 2000 (Thrombosis) : However, when HUVECs were incubated with LPS plus ligustrazini, the upregulation of PAI-1 by LPS was abated
Ruan et al., Zhonghua Bing Li Xue Za Zhi 2000 : However, when HUVECs were incubated with LPS plus anisodamine, the upregulation of PAI-1 by LPS was significantly abated ... The inhibition of anisodamine on LPS induced PAI-1 in ECs may take place via the NF-kappaB pathway
Yamamoto et al., Am J Pathol 2002 (Thrombosis) : Since elevated plasminogen activator inhibitor-1 ( PAI-1 ) primarily contributes to endotoxin induced thrombosis, we first compared the induction of PAI-1 by lipopolysaccharide (LPS) between young and aged mice
Falanga et al., Leukemia 2003 : Specifically, it dose-dependently counteracted the LPS induced increase in PAI-1 levels and decrease in t-PA activity expression
Bergheim et al., J Pharmacol Exp Ther 2006 (Inflammation) : Furthermore, PH/LPS caused a > 200x increase in hepatic plasminogen activator inhibitor 1 ( PAI-1 ) mRNA expression and plasma PAI-1 protein
Slivka et al., Biochim Biophys Acta 1991 : Agents which increase cAMP, ( e.g., forskolin and isobutylmethylxanthine ) blocked the induction of PAI-1 synthesis by PMA, LPS , TGF beta and TNF alpha suggesting that induction may occur by lowering cAMP
Hecke et al., Thromb Haemost 2006 : Moreover, siRNA treatment reduced the activity of PAI-1 released from HUVEC, and prevented the oxLDL- or LPS induced upregulation of PAI-1 secretion
Arndt et al., J Immunol 2006 : LPS induced PAI-1 levels were diminished in animals pretreated with losartan and in those deficient for the ATII receptor 1a
Hsieh et al., J Rheumatol 2007 (Osteoarthritis, Knee) : Our findings were : ( 1 ) latent and active forms of MMP-9 secretion in synovial and some meniscal cultures were inhibited significantly by U0126, SB203580, and LY294002 ; ( 2 ) latent and active forms of MMP-2 secretion were also inhibited significantly by U0126 and LY294002, but not by SB203580, except for active MMP-2 in synovial cultures ; ( 3 ) a similar observation was seen in IL-1alpha- and LPS treated cultures ; and ( 4 ) U0126, SB203580, and LY294002 significantly decreased u-PA and PAI-1 levels in all cultures in the presence or absence of IL-1alpha and LPS
Hagiwara et al., J Anesth 2007 (Disease Models, Animal...) : Furthermore, the LPS induced increases in PAI-1 activity and in plasma TNF-alpha concentrations were also lower in the rats given both NM and LPS than in the rats given LPS alone
Kowal et al., J Investig Allergol Clin Immunol 2008 (Asthma...) : On the other hand, LPS induces PAI-1 secretion
Sawdey et al., J Clin Invest 1991 : However, the greatest responses to TGF-beta were observed in adipose tissue and the kidney, while LPS and TNF-alpha strongly stimulated PAI-1 gene expression in the liver, kidney, lung, and adrenals ... In C3H/HeJ mice, which exhibit defective TNF-alpha release in response to LPS, the response of the PAI-1 gene to LPS was severely attenuated
Chen et al., Arch Biochem Biophys 2011 (Inflammation) : Luciferase reporter assays showed that PAI-1 promoter activity was induced by TNFa or LPS , and the induction was blocked by 1,25 ( OH ) 2D3 ... In mice LPS stimulated PAI-1 expression in the heart and macrophages, and the stimulation was blunted by pre-treatment with a vitamin D analog
Kwon et al., J Neurosci Res 2011 : Interestingly, hydrocortisone further increased LPS induced up-regulation of PAI-1 while inhibiting the up-regulation of iNOS and COX-2 expression
van den Berg et al., Thromb Haemost 1988 : Cultured human endothelial cells increase their PAI-1 production upon stimulation with LPS and TNF, agents that are known to cause an increase in PAI-1 levels in vivo
Soeda et al., Biochim Biophys Acta 1995 : In this study, we examined the effects of oversulfated fucoidan ( OSF ) derivatives and heparin on lipopolysaccharide (LPS) induced release of PAI-1 antigen from cultured human umbilical vein endothelial cells ( HUVEC ) ... Treatment of HUVEC with heparitinase or monoclonal antibody against heparin sulfate proteoglycan (HSPG) resulted in a complete loss of its ability to enhance PAI-1 release in response to LPS stimulation, while the chondroitinase ABC treatment hardly affected the PAI-1 production ... The suppressive effects of OSF and heparin on LPS induced PAI-1 release may result from the inhibition of LPS binding to the cell surface HSPG
Samad et al., Biochim Biophys Acta 1994 : We further showed that LPS induces a 70 % increase in secreted IL-6 and a 50 % increase in PAI-1 protein levels ... Increasing doses of anti-IL-6 completely blocked the effect of LPS on PAI-1 while non-specific antibodies had no effect
Matsumoto et al., Life Sci 1996 : The PA activity recovered from the cell surface fraction was not affected by LPS stimulation, but the PAI-1 activity was increased
Gallicchio et al., J Immunol 1996 : Northern blot analysis paralleled protein results, showing decreases in specific endothelial cell thrombin- or LPS induced PAI-1 mRNA expression, respectively, after incubation with IFN-gamma for 24 h
Fearns et al., Am J Pathol 1997 : To determine possible mechanisms involved in the induction of PAI-1 by LPS , we analyzed the tissues for changes in tumor necrosis factor (TNF)-alpha LPS caused a rapid induction of TNF-alpha mRNA in Kupffer cells, detectable within 15 minutes ... These results suggest that LPS may induce PAI-1 in endothelial cells and hepatocytes by different mechanisms
Zhang et al., Arterioscler Thromb Vasc Biol 1997 : The 2.5- and 3.4-fold ( 2.2- and 3.2-kb ) increases in PAI-1 mRNA levels induced by LPS ( 1 microgram/mL for 6 hours ) were reduced to 1.4- and 2.6-fold increases in the presence of both LPS and 100 micrograms/mL NG-R1