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IGF1 — NOS2
Text-mined interactions from Literome
Guan et al., Neuroscience 2000
(Brain Ischemia) :
Insulin-like growth factor-1 markedly
prevented the loss of calbindin-28kd ( n = 7, P < 0.05 ), choline acetyltransferase ( n = 7, P < 0.05 ), neuropeptide Y ( n = 7, P < 0.05 ), neuronal
nitric oxide synthase ( n = 8, P < 0.05 ) and glutamate acid decarboxylase ( n = 9, P < 0.05 ) immunopositive neurons, but failed to protect parvalbumin ( n = 6 ) immunopositive neurons
Castrillo et al., Diabetes 2000
:
Inhibitory
effect of
IGF-I on type 2
nitric oxide synthase expression in Ins-1 cells and protection against activation dependent apoptosis : involvement of phosphatidylinositol 3-kinase
Isenovic et al., Metabolism 2003
:
Interactive
effects of
insulin-like growth factor-1 and beta-estradiol on endothelial
nitric oxide synthase activity in rat aortic endothelial cells
Priego et al., J Endocrinol 2006
:
In addition, two specific
inducible NO synthase (iNOS) inhibitors, l-N6- ( 1-iminoethyl ) lysine ( l-NIL ) and aminoguanidine,
prevented the effect of LPS on nitrite+nitrate levels and on
IGF-I gene expression in hepatocyte cultures ... We conclude that in hepatocytes, LPS induced decrease in
IGF-I is mainly
due to induction of
iNOS , whereas in the presence of Kupffer cells LPS inhibits IGF-I through NO release and through other inhibitory pathways
Thum et al., Circ Res 2007
:
IGF-1 increased telomerase activity, endothelial
nitric oxide synthase expression, phosphorylation and activity in EPC in a phosphoinositide-3-kinase/Akt dependent manner
Zakula et al., Med Hypotheses 2007
(Diabetes Mellitus, Experimental...) :
Understanding how
iNOS and sodium pump activity are
regulated by
IGF-1 activation of the PI3K/cPLA(2)/Akt cascade should provide novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation
Hijikawa et al., Shock 2008
(Liver Failure) :
We hypothesized that
IGF-1 inhibited the induction of these cytokines and
iNOS , resulting in beneficial effect in the liver ...
Insulin-like growth factor 1 may
inhibit the induction of proinflammatory cytokines and
iNOS through an nuclear factor-kappa B-independent pathway and have a novel therapeutic potential in the prevention of liver injury
Hirai et al., Life Sci 2011
(Atherosclerosis...) :
In group HIGF,
IGF led to atheromas with increased plasma insulin growth factor binding protein 3 ( IBP3 ),
inducible nitric oxide synthase(iNOS) expression and nitrotyrosine staining, macrophage staining, SM1 staining and SM embryo staining compared to HC
Stone et al., J Gerontol A Biol Sci Med Sci 2012
:
Moreover,
IGF-1 also
activated endothelial
nitric oxide synthase in human umbilical vein endothelial cells
Guan et al., Am J Physiol 1998
:
We demonstrate that both insulin and
IGF-I increase IL-1 beta induced Cox-2 and
iNOS protein expression, which in turn enhance PGE2 and NO production