◀ Back to IL13

IL13 — TIMP1

Text-mined interactions from Literome

Cleaver et al., Ann Rheum Dis 2001 : Northern blot analyses were performed to determine the effects of IL13 on the induction of matrix metalloproteinase-1 (MMP-1), MMP-3, MMP-13, and TIMP-1 gene expression ... Northern blot analysis showed that IL13 down regulated MMP-3 and MMP-13 levels but up regulated MMP-1 and TIMP-1 gene expression in bovine nasal chondrocytes at 24 hours
Zhou et al., Am J Physiol Cell Physiol 2005 : The specific PI3K inhibitor LY-294002 in the presence of TGF-beta1, IL-13, or the combination of the two caused significant increases in TIMP-1 mRNA expression, while LY-294002 increased TIMP-1 protein levels in the presence of IL-13 alone
Zhou et al., J Allergy Clin Immunol 2007 (Asthma...) : IL-13 alone does not induce TIMP-1 , but in combination with TGF-beta it augments TIMP-1 expression ... These results indicate that IL-13 augments TGF-beta1 induced TIMP-1 expression through increased Smad phosphorylation
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments